TC3 more effective in the HRD+ biomarker signature
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.024, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 41.8, median = 34.2 | mean = 39, median = 31.9 |
| all | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.07, hr = 0.91 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39.9, median = 32.6 | mean = 39, median = 31.9 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.02, hr = 0.97 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 42.7, median = 34.8 | mean = 39, median = 31.9 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.09, hr = 0.89 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.024, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 40.5, median = 33.1 | mean = 39, median = 31.9 |
| PI3K+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1.04, hr = 0.95 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 1, hr = 1 | af = 1, hr = 1 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +— | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +–+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +-+- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +-++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| ++– | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| ++-+ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| +++- | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.027, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 34.3, median = 28 | mean = 34.3, median = 28 | mean = 78.1, median = 63.8 | mean = 39, median = 31.9 |
| ++++ | effect | af = 1, hr = 1 | af = 0.88, hr = 1.18 | af = 0.88, hr = 1.18 | af = 2, hr = 0.41 | af = 1, hr = 1 |
|
|
|
|
|
|
| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.376 | 0.05 | 0.034 | 0.170 | 0.172 |
| Error subgroup | 0.492 | 0.05 | 0.034 | 0.334 | 0.172 |
| Power signature | 0.642 | 0.00 | 0.000 | 0.642 | 0.000 |
| Power subgroup | 0.812 | 0.00 | 0.000 | 0.812 | 0.000 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 6 | 3 | 73 | 26 |
| all | futility | 0 | 15 | 24 | 0 | 1 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 612 (562, 676) | 263 (188, 354) | 262 (181, 354) | 328 (164, 428) | 338 (233, 446) |
| all | n_unique | 612 (562, 676) | 263 (188, 354) | 262 (181, 354) | 328 (164, 428) | 338 (233, 446) |
| all | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (28, 60) | 60 (60, 60) |
| all | time_stop | NA (NA, NA) | 30 (10, 53) | 36 (11, 55) | 20 (12, 49) | 15 (12, 36) |
| all | post_p | NA (NA, NA) | 0.28 (0.04, 0.75) | 0.3 (0.04, 0.75) | 0.99 (0.9, 1) | 0.84 (0.38, 0.99) |
| all | rate | 0.023 (0.022, 0.025) | 0.025 (0.022, 0.028) | 0.025 (0.023, 0.028) | 0.018 (0.017, 0.02) | 0.021 (0.019, 0.024) |
| HRD+ | graduation | 0 | 2 | 3 | 321 | 21 |
| HRD+ | futility | 0 | 8 | 6 | 0 | 10 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 85 (71, 100) | 38 (23, 57) | 38 (24, 54) | 52 (34, 72) | 43 (27, 61) |
| HRD+ | n_unique | 85 (71, 100) | 38 (23, 57) | 38 (24, 54) | 52 (34, 72) | 43 (27, 61) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 51 (39, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 56 (50, 60) | 58 (48, 60) | 45 (37, 55) | 53 (41, 59) |
| HRD+ | post_p | NA (NA, NA) | 0.36 (0.08, 0.8) | 0.37 (0.07, 0.8) | 1 (0.98, 1) | 0.55 (0.15, 0.94) |
| HRD+ | rate | 0.023 (0.019, 0.028) | 0.025 (0.019, 0.033) | 0.024 (0.018, 0.033) | 0.009 (0.007, 0.013) | 0.022 (0.016, 0.029) |
| TP53+ | graduation | 0 | 9 | 3 | 49 | 26 |
| TP53+ | futility | 0 | 106 | 140 | 17 | 47 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 228 (202, 260) | 100 (55, 152) | 102 (54, 149) | 113 (51, 165) | 125 (59, 178) |
| TP53+ | n_unique | 228 (202, 260) | 100 (55, 152) | 102 (54, 149) | 113 (51, 165) | 125 (59, 178) |
| TP53+ | time_trial | 60 (60, 60) | 60 (40, 60) | 60 (29, 60) | 60 (47, 60) | 60 (42, 60) |
| TP53+ | time_stop | NA (NA, NA) | 42 (28, 54) | 35 (21, 52) | 36 (24, 56) | 35 (26, 57) |
| TP53+ | post_p | NA (NA, NA) | 0.36 (0.06, 0.8) | 0.38 (0.05, 0.81) | 0.82 (0.36, 0.98) | 0.72 (0.25, 0.97) |
| TP53+ | rate | 0.023 (0.02, 0.026) | 0.025 (0.021, 0.031) | 0.025 (0.022, 0.031) | 0.02 (0.017, 0.025) | 0.021 (0.018, 0.026) |
| TEfus+ | graduation | 0 | 6 | 7 | 52 | 21 |
| TEfus+ | futility | 0 | 83 | 93 | 2 | 29 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 197 (172, 224) | 89 (56, 128) | 90 (53, 137) | 100 (50, 139) | 109 (59, 151) |
| TEfus+ | n_unique | 197 (172, 224) | 89 (56, 128) | 90 (53, 137) | 100 (50, 139) | 109 (59, 151) |
| TEfus+ | time_trial | 60 (60, 60) | 60 (44, 60) | 60 (40, 60) | 60 (56, 60) | 60 (60, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 42 (31, 56) | 40 (29, 56) | 41 (30, 54) | 36 (25, 56) |
| TEfus+ | post_p | NA (NA, NA) | 0.36 (0.06, 0.81) | 0.35 (0.06, 0.8) | 0.94 (0.64, 1) | 0.71 (0.2, 0.96) |
| TEfus+ | rate | 0.023 (0.02, 0.026) | 0.025 (0.021, 0.031) | 0.025 (0.021, 0.031) | 0.018 (0.015, 0.021) | 0.021 (0.018, 0.026) |
| PI3K+ | graduation | 0 | 3 | 1 | 44 | 13 |
| PI3K+ | futility | 0 | 73 | 97 | 2 | 54 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 212 (187, 239) | 100 (59, 142) | 97 (54, 145) | 105 (50, 146) | 121 (57, 172) |
| PI3K+ | n_unique | 212 (187, 239) | 100 (59, 142) | 97 (54, 145) | 105 (50, 146) | 121 (57, 172) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (50, 60) | 60 (41, 60) | 60 (60, 60) | 60 (44, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 43 (30, 56) | 39 (28, 57) | 39 (26, 54) | 33 (24, 53) |
| PI3K+ | post_p | NA (NA, NA) | 0.4 (0.07, 0.82) | 0.37 (0.06, 0.79) | 0.85 (0.42, 0.98) | 0.73 (0.24, 0.97) |
| PI3K+ | rate | 0.023 (0.02, 0.026) | 0.024 (0.021, 0.03) | 0.025 (0.021, 0.031) | 0.02 (0.016, 0.024) | 0.022 (0.018, 0.026) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 6 | 3 | 73 | 26 |
| —- | futility | 0 | 15 | 24 | 0 | 1 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 190 (158, 224) | 63 (28, 141) | 60 (25, 134) | 98 (25, 179) | 104 (29, 181) |
| —- | n_unique | 190 (158, 224) | 63 (28, 141) | 60 (25, 134) | 98 (25, 179) | 104 (29, 181) |
| —- | post_p | NA (NA, NA) | 0.34 (0.06, 0.79) | 0.32 (0.07, 0.78) | 0.68 (0.21, 0.97) | 0.67 (0.2, 0.96) |
| —- | rate | 0.023 (0.02, 0.026) | 0.027 (0.021, 0.035) | 0.026 (0.021, 0.035) | 0.021 (0.017, 0.028) | 0.021 (0.017, 0.028) |
| —+ | graduation | 0 | 9 | 4 | 105 | 36 |
| —+ | futility | 0 | 80 | 107 | 2 | 54 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 42 (33, 53) | 19 (9, 37) | 17 (8, 37) | 20 (7, 41) | 22 (9, 42) |
| —+ | n_unique | 42 (33, 53) | 19 (9, 37) | 17 (8, 37) | 20 (7, 41) | 22 (9, 42) |
| —+ | post_p | NA (NA, NA) | 0.42 (0.1, 0.81) | 0.44 (0.11, 0.8) | 0.6 (0.19, 0.92) | 0.58 (0.17, 0.91) |
| —+ | rate | 0.023 (0.017, 0.03) | 0.026 (0.017, 0.04) | 0.025 (0.017, 0.042) | 0.022 (0.013, 0.036) | 0.022 (0.015, 0.036) |
| –+- | graduation | 0 | 12 | 10 | 117 | 44 |
| –+- | futility | 0 | 89 | 104 | 2 | 29 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 12 (8, 19) | 7 (3, 13) | 7 (3, 13) | 6 (2, 12) | 6 (2, 13) |
| –+- | n_unique | 12 (8, 19) | 7 (3, 13) | 7 (3, 13) | 6 (2, 12) | 6 (2, 13) |
| –+- | post_p | NA (NA, NA) | 0.45 (0.17, 0.79) | 0.45 (0.18, 0.75) | 0.52 (0.24, 0.81) | 0.51 (0.22, 0.8) |
| –+- | rate | 0.023 (0.012, 0.036) | 0.026 (0.012, 0.056) | 0.025 (0.012, 0.053) | 0.022 (0.008, 0.048) | 0.024 (0.01, 0.055) |
| –++ | graduation | 0 | 14 | 11 | 140 | 53 |
| –++ | futility | 0 | 135 | 159 | 4 | 75 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 66 (51, 79) | 24 (10, 53) | 23 (10, 57) | 26 (9, 57) | 32 (13, 65) |
| –++ | n_unique | 66 (51, 79) | 24 (10, 53) | 23 (10, 57) | 26 (9, 57) | 32 (13, 65) |
| –++ | post_p | NA (NA, NA) | 0.43 (0.09, 0.81) | 0.38 (0.08, 0.81) | 0.61 (0.17, 0.92) | 0.58 (0.18, 0.93) |
| –++ | rate | 0.023 (0.018, 0.029) | 0.026 (0.019, 0.038) | 0.026 (0.019, 0.042) | 0.022 (0.015, 0.036) | 0.022 (0.016, 0.032) |
| -+– | graduation | 0 | 15 | 5 | 111 | 48 |
| -+– | futility | 0 | 113 | 150 | 17 | 47 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 81 (65, 98) | 30 (13, 68) | 28 (14, 59) | 33 (11, 76) | 40 (13, 76) |
| -+– | n_unique | 81 (65, 98) | 30 (13, 68) | 28 (14, 59) | 33 (11, 76) | 40 (13, 76) |
| -+– | post_p | NA (NA, NA) | 0.42 (0.07, 0.83) | 0.41 (0.08, 0.82) | 0.61 (0.16, 0.94) | 0.6 (0.19, 0.92) |
| -+– | rate | 0.023 (0.019, 0.028) | 0.026 (0.019, 0.038) | 0.026 (0.019, 0.037) | 0.022 (0.016, 0.033) | 0.022 (0.016, 0.033) |
| -+-+ | graduation | 0 | 18 | 6 | 135 | 57 |
| -+-+ | futility | 0 | 156 | 192 | 19 | 86 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 53 (42, 66) | 20 (8, 47) | 20 (9, 45) | 22 (8, 47) | 27 (11, 53) |
| -+-+ | n_unique | 53 (42, 66) | 20 (8, 47) | 20 (9, 45) | 22 (8, 47) | 27 (11, 53) |
| -+-+ | post_p | NA (NA, NA) | 0.42 (0.1, 0.84) | 0.41 (0.09, 0.79) | 0.59 (0.2, 0.91) | 0.6 (0.18, 0.93) |
| -+-+ | rate | 0.023 (0.018, 0.029) | 0.025 (0.017, 0.041) | 0.026 (0.019, 0.04) | 0.022 (0.014, 0.036) | 0.021 (0.015, 0.033) |
| -++- | graduation | 0 | 20 | 12 | 149 | 61 |
| -++- | futility | 0 | 163 | 206 | 19 | 71 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 47 (37, 59) | 17 (8, 39) | 18 (9, 40) | 20 (7, 44) | 23 (7, 47) |
| -++- | n_unique | 47 (37, 59) | 17 (8, 39) | 18 (9, 40) | 20 (7, 44) | 23 (7, 47) |
| -++- | post_p | NA (NA, NA) | 0.39 (0.09, 0.83) | 0.39 (0.1, 0.79) | 0.6 (0.19, 0.91) | 0.59 (0.21, 0.93) |
| -++- | rate | 0.023 (0.017, 0.03) | 0.026 (0.018, 0.043) | 0.026 (0.018, 0.04) | 0.021 (0.014, 0.035) | 0.021 (0.014, 0.033) |
| -+++ | graduation | 0 | 22 | 13 | 166 | 69 |
| -+++ | futility | 0 | 193 | 234 | 21 | 106 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 36 (28, 47) | 15 (6, 33) | 14 (6, 35) | 15 (5, 32) | 18 (7, 37) |
| -+++ | n_unique | 36 (28, 47) | 15 (6, 33) | 14 (6, 35) | 15 (5, 32) | 18 (7, 37) |
| -+++ | post_p | NA (NA, NA) | 0.44 (0.12, 0.78) | 0.4 (0.13, 0.8) | 0.58 (0.2, 0.87) | 0.53 (0.21, 0.86) |
| -+++ | rate | 0.023 (0.017, 0.031) | 0.026 (0.017, 0.042) | 0.027 (0.016, 0.042) | 0.022 (0.014, 0.04) | 0.023 (0.015, 0.036) |
| +— | graduation | 0 | 8 | 6 | 385 | 47 |
| +— | futility | 0 | 22 | 30 | 0 | 11 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 41 (32, 51) | 16 (7, 30) | 15 (7, 31) | 27 (14, 40) | 18 (7, 31) |
| +— | n_unique | 41 (32, 51) | 16 (7, 30) | 15 (7, 31) | 27 (14, 40) | 18 (7, 31) |
| +— | post_p | NA (NA, NA) | 0.38 (0.1, 0.79) | 0.38 (0.1, 0.8) | 0.98 (0.81, 1) | 0.5 (0.16, 0.86) |
| +— | rate | 0.023 (0.017, 0.031) | 0.025 (0.016, 0.043) | 0.025 (0.015, 0.043) | 0.009 (0.005, 0.015) | 0.022 (0.014, 0.036) |
| +–+ | graduation | 0 | 11 | 7 | 391 | 54 |
| +–+ | futility | 0 | 86 | 111 | 2 | 61 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +–+ | rate | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.174) | 0 (0, 0) | 0 (0, 0.02) |
| +-+- | graduation | 0 | 14 | 13 | 395 | 64 |
| +-+- | futility | 0 | 96 | 109 | 2 | 37 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 28 (21, 38) | 11 (5, 22) | 11 (5, 22) | 18 (8, 27) | 13 (5, 25) |
| +-+- | n_unique | 28 (21, 38) | 11 (5, 22) | 11 (5, 22) | 18 (8, 27) | 13 (5, 25) |
| +-+- | post_p | NA (NA, NA) | 0.36 (0.1, 0.74) | 0.37 (0.11, 0.74) | 0.94 (0.73, 1) | 0.52 (0.17, 0.87) |
| +-+- | rate | 0.023 (0.016, 0.031) | 0.026 (0.015, 0.05) | 0.026 (0.014, 0.049) | 0.009 (0.005, 0.016) | 0.021 (0.011, 0.041) |
| +-++ | graduation | 0 | 16 | 14 | 400 | 71 |
| +-++ | futility | 0 | 141 | 163 | 4 | 82 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 6 (3, 10) | 4 (1, 7) | 3 (1, 6) | 3 (1, 6) | 4 (1, 7) |
| +-++ | n_unique | 6 (3, 10) | 4 (1, 7) | 3 (1, 6) | 3 (1, 6) | 4 (1, 7) |
| +-++ | post_p | NA (NA, NA) | 0.48 (0.28, 0.65) | 0.46 (0.28, 0.65) | 0.59 (0.45, 0.78) | 0.48 (0.29, 0.67) |
| +-++ | rate | 0.025 (0.007, 0.048) | 0.024 (0, 0.055) | 0.027 (0, 0.081) | 0.009 (0, 0.031) | 0.022 (0, 0.056) |
| ++– | graduation | 0 | 15 | 8 | 392 | 66 |
| ++– | futility | 0 | 120 | 154 | 8 | 56 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.49 (0.43, 0.57) | 0.49 (0.43, 0.56) | 0.53 (0.45, 0.59) | 0.51 (0.44, 0.57) |
| ++– | rate | 0.022 (0, 0.086) | 0.022 (0, 0.092) | 0.027 (0, 0.108) | 0 (0, 0.049) | 0.016 (0, 0.1) |
| ++-+ | graduation | 0 | 18 | 9 | 397 | 72 |
| ++-+ | futility | 0 | 162 | 194 | 10 | 92 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 7 (4, 12) | 4 (1, 8) | 4 (1, 8) | 4 (1, 9) | 5 (2, 9) |
| ++-+ | n_unique | 7 (4, 12) | 4 (1, 8) | 4 (1, 8) | 4 (1, 9) | 5 (2, 9) |
| ++-+ | post_p | NA (NA, NA) | 0.44 (0.25, 0.67) | 0.46 (0.25, 0.69) | 0.64 (0.47, 0.89) | 0.47 (0.26, 0.7) |
| ++-+ | rate | 0.023 (0.01, 0.044) | 0.027 (0.008, 0.069) | 0.025 (0.006, 0.062) | 0.008 (0, 0.024) | 0.023 (0.008, 0.055) |
| +++- | graduation | 0 | 20 | 15 | 399 | 78 |
| +++- | futility | 0 | 170 | 209 | 10 | 78 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +++- | rate | 0 (0, 0.135) | 0.086 (0.017, 0.177) | 0.053 (0.049, 0.056) | 0 (0, 0.041) | 0 (0, 0) |
| ++++ | graduation | 0 | 22 | 16 | 403 | 84 |
| ++++ | futility | 0 | 199 | 236 | 12 | 112 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | 0.52 (0.51, 0.52) | 0.51 (0.48, 0.54) | 0.51 (0.48, 0.54) | 0.52 (0.51, 0.52) |
| ++++ | rate | 0 (0, 0.195) | 0.021 (0, 0.092) | 0.036 (0, 0.127) | 0.007 (0, 0.084) | 0.015 (0, 0.087) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| all | count | 6 | 3 | 73 | 26 |
| all | time_stop | 10 (9, 19) | 11 (11, 17) | 20 (12, 49) | 15 (12, 32) |
| all | n_trt | 66 (60, 120) | 72 (72, 100) | 110 (60, 276) | 86 (56, 217) |
| all | n_control | 80 (71, 162) | 95 (89, 135) | 166 (99, 477) | 122 (94, 285) |
| all | post_p | 0.96 (0.88, 0.99) | 0.94 (0.92, 0.96) | 0.97 (0.91, 1) | 0.96 (0.91, 0.99) |
| all | order | 1 (1, 1.5) | 1 (1, 1) | 1 (1, 2.8) | 1 (1, 2) |
| HRD+ | count | 2 | 3 | 321 | 21 |
| HRD+ | time_stop | 55 (51, 59) | 49 (45, 58) | 45 (37, 55) | 50 (41, 58) |
| HRD+ | n_trt | 52 (51, 54) | 50 (50, 51) | 52 (50, 64) | 52 (50, 62) |
| HRD+ | n_control | 76 (74, 78) | 69 (66, 84) | 59 (44, 77) | 67 (49, 76) |
| HRD+ | post_p | 0.94 (0.89, 0.99) | 0.99 (0.94, 0.99) | 1 (0.96, 1) | 0.97 (0.92, 1) |
| HRD+ | order | 2 (2, 2) | 2 (2, 2) | 1 (1, 2) | 2 (1, 3) |
| TP53+ | count | 9 | 3 | 49 | 26 |
| TP53+ | time_stop | 26 (23, 55) | 48 (45, 54) | 35 (24, 53) | 36 (23, 56) |
| TP53+ | n_trt | 60 (52, 143) | 105 (103, 119) | 75 (51, 115) | 80 (55, 152) |
| TP53+ | n_control | 85 (68, 213) | 183 (147, 189) | 114 (73, 208) | 124 (72, 198) |
| TP53+ | post_p | 0.96 (0.92, 0.98) | 0.97 (0.94, 0.99) | 0.97 (0.93, 1) | 0.97 (0.9, 1) |
| TP53+ | order | 1 (1, 2) | 2 (1.2, 2.8) | 1 (1, 3) | 2 (1, 3.5) |
| TEfus+ | count | 6 | 7 | 52 | 21 |
| TEfus+ | time_stop | 28 (25, 38) | 36 (33, 47) | 41 (30, 54) | 28 (24, 48) |
| TEfus+ | n_trt | 54 (51, 62) | 92 (57, 103) | 81 (55, 124) | 61 (50, 109) |
| TEfus+ | n_control | 78 (61, 114) | 118 (91, 135) | 127 (77, 173) | 81 (64, 156) |
| TEfus+ | post_p | 0.95 (0.86, 0.97) | 0.94 (0.88, 0.99) | 0.99 (0.94, 1) | 0.99 (0.89, 1) |
| TEfus+ | order | 1 (1, 1.5) | 1 (1, 2.8) | 2 (1, 3) | 1 (1, 3) |
| PI3K+ | count | 3 | 1 | 44 | 13 |
| PI3K+ | time_stop | 32 (27, 38) | 33 (33, 33) | 39 (26, 55) | 45 (27, 56) |
| PI3K+ | n_trt | 64 (56, 69) | 67 (67, 67) | 76 (51, 124) | 104 (62, 140) |
| PI3K+ | n_control | 86 (69, 108) | 112 (112, 112) | 124 (72, 195) | 143 (82, 195) |
| PI3K+ | post_p | 0.94 (0.89, 0.98) | 0.96 (0.96, 0.96) | 0.99 (0.95, 1) | 0.99 (0.96, 1) |
| PI3K+ | order | 1 (1, 1) | 1 (1, 1) | 2 (1, 3.7) | 2 (1, 4) |
| signature | var | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| all | count | 15 | 24 | 1 | |
| all | time_stop | 41 (22, 53) | 38 (11, 56) | 40 (40, 40) | |
| all | n_trt | 152 (102, 243) | 138 (67, 216) | 132 (132, 132) | |
| all | n_control | 426 (180, 549) | 354 (90, 592) | 367 (367, 367) | |
| all | post_p | 0.01 (0, 0.09) | 0.03 (0, 0.16) | 0.02 (0.02, 0.02) | |
| all | order | 2 (1, 4) | 2.5 (1, 4.7) | 3 (3, 3) | |
| HRD+ | count | 8 | 6 | 10 | |
| HRD+ | time_stop | 56 (53, 59) | 58 (52, 60) | 57 (52, 60) | |
| HRD+ | n_trt | 55 (52, 57) | 50 (50, 64) | 54 (50, 60) | |
| HRD+ | n_control | 87 (73, 96) | 80 (72, 86) | 80 (69, 100) | |
| HRD+ | post_p | 0.17 (0.01, 0.29) | 0.2 (0.07, 0.28) | 0.2 (0.12, 0.27) | |
| HRD+ | order | 2.5 (1, 5) | 2.5 (1.5, 4.5) | 2.5 (1.9, 4) | |
| TP53+ | count | 106 | 140 | 17 | 47 |
| TP53+ | time_stop | 42 (30, 54) | 34 (21, 52) | 41 (29, 56) | 35 (27, 56) |
| TP53+ | n_trt | 66 (50, 98) | 62 (51, 98) | 54 (51, 115) | 59 (50, 94) |
| TP53+ | n_control | 153 (88, 202) | 115 (62, 190) | 135 (95, 217) | 117 (81, 212) |
| TP53+ | post_p | 0.1 (0.01, 0.23) | 0.11 (0.02, 0.25) | 0.13 (0.04, 0.23) | 0.12 (0.03, 0.24) |
| TP53+ | order | 2 (1, 3) | 1 (1, 3) | 1 (1, 2.4) | 2 (1, 3) |
| TEfus+ | count | 83 | 93 | 2 | 29 |
| TEfus+ | time_stop | 42 (32, 57) | 40 (29, 56) | 38 (34, 41) | 39 (30, 57) |
| TEfus+ | n_trt | 66 (52, 95) | 61 (51, 92) | 66 (53, 78) | 63 (50, 92) |
| TEfus+ | n_control | 130 (87, 186) | 118 (73, 187) | 112 (104, 119) | 114 (82, 190) |
| TEfus+ | post_p | 0.1 (0.02, 0.21) | 0.1 (0.02, 0.19) | 0.12 (0.11, 0.13) | 0.14 (0.03, 0.26) |
| TEfus+ | order | 2 (1, 3) | 2 (1, 3.8) | 1 (1, 1) | 1 (1, 3.2) |
| PI3K+ | count | 73 | 97 | 2 | 54 |
| PI3K+ | time_stop | 44 (30, 57) | 39 (28, 57) | 46 (44, 48) | 32 (23, 48) |
| PI3K+ | n_trt | 65 (50, 98) | 62 (51, 95) | 70 (65, 74) | 57 (50, 90) |
| PI3K+ | n_control | 144 (87, 198) | 128 (76, 203) | 160 (149, 172) | 100 (62, 154) |
| PI3K+ | post_p | 0.09 (0.03, 0.21) | 0.1 (0.02, 0.2) | 0.09 (0.08, 0.09) | 0.13 (0.04, 0.25) |
| PI3K+ | order | 2 (1, 3) | 2 (1, 4) | 2.5 (1.3, 3.7) | 1.5 (1, 3) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| all | TC1 | time | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) | 10 (9, 19) |
| all | TC1 | n | 28 (23, 39) | 6 (4, 16) | 1 (0, 2) | 7 (3, 14) | 9 (6, 15) | 6 (5, 11) | 4 (3, 12) | 4 (0, 6) | 4 (1, 6) | 0 (0, 0) | 2 (0, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.64 (0.6, 0.78) | 0.55 (0.52, 0.76) | 0.51 (0.51, 0.52) | 0.58 (0.52, 0.61) | 0.56 (0.53, 0.57) | 0.53 (0.51, 0.6) | 0.57 (0.54, 0.61) | 0.53 (0.5, 0.53) | 0.53 (0.5, 0.58) | NA (NA, NA) | 0.53 (0.51, 0.56) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.52 (0.51, 0.53) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.27 (0.27, 0.27) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.009 (0, 0.015) | 0 (0, 0.002) | 0 (0, 0) | 0 (0, 0.027) | 0 (0, 0.011) | 0 (0, 0.017) | 0 (0, 0.011) | 0 (0, 0.007) | 0 (0, 0.007) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| all | TC2 | time | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) | 11 (11, 17) |
| all | TC2 | n | 26 (24, 28) | 2 (2, 10) | 1 (0, 3) | 8 (6, 9) | 16 (15, 21) | 8 (8, 11) | 8 (4, 9) | 5 (2, 5) | 3 (3, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 1 (0, 2) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.52 (0.51, 0.61) | 0.53 (0.52, 0.57) | 0.53 (0.52, 0.54) | 0.56 (0.56, 0.68) | 0.56 (0.55, 0.61) | 0.5 (0.5, 0.65) | 0.57 (0.54, 0.57) | 0.54 (0.53, 0.56) | 0.53 (0.51, 0.53) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | NA (NA, NA) | 0.51 (0.51, 0.52) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.013 (0.008, 0.019) | 0 (0, 0.016) | 0.014 (0.003, 0.024) | 0 (0, 0.019) | 0.005 (0.001, 0.008) | 0.021 (0.004, 0.024) | 0 (0, 0.008) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 |
| all | TC3 | time | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) | 20 (12, 49) |
| all | TC3 | n | 31 (14, 92) | 7 (3, 23) | 2 (0, 7) | 10 (4, 27) | 14 (6, 32) | 8 (3, 23) | 8 (3, 19) | 7 (2, 18) | 12 (7, 25) | 0 (0, 0) | 9 (4, 16) | 1 (0, 5) | 0 (0, 1) | 2 (0, 6) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.65 (0.54, 0.89) | 0.56 (0.51, 0.82) | 0.55 (0.51, 0.78) | 0.56 (0.52, 0.78) | 0.58 (0.51, 0.82) | 0.58 (0.52, 0.8) | 0.56 (0.51, 0.72) | 0.56 (0.52, 0.78) | 0.59 (0.52, 0.99) | NA (NA, NA) | 0.57 (0.51, 0.85) | 0.54 (0.51, 0.62) | 0.56 (0.52, 0.57) | 0.53 (0.5, 0.62) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.013 (0, 0.021) | 0 (0, 0.02) | 0 (0, 0.017) | 0.011 (0, 0.023) | 0.009 (0, 0.024) | 0.007 (0, 0.022) | 0 (0, 0.021) | 0.01 (0, 0.022) | 0.004 (0, 0.013) | NA (NA, NA) | 0 (0, 0.017) | 0 (0, 0.017) | 0 (0, 0.014) | 0 (0, 0.011) | NA (NA, NA) | 0 (0, 0) |
| all | TC4 | count | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 |
| all | TC4 | time | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) | 15 (12, 32) |
| all | TC4 | n | 25 (14, 70) | 7 (3, 16) | 1 (0, 4) | 12 (5, 26) | 9 (4, 28) | 10 (4, 23) | 5 (2, 10) | 7 (4, 13) | 4 (2, 16) | 0 (0, 0) | 3 (0, 7) | 2 (0, 3) | 0 (0, 1) | 1 (0, 4) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.7 (0.54, 0.85) | 0.56 (0.52, 0.64) | 0.52 (0.51, 0.59) | 0.56 (0.52, 0.82) | 0.57 (0.53, 0.76) | 0.57 (0.51, 0.81) | 0.54 (0.51, 0.64) | 0.55 (0.51, 0.65) | 0.55 (0.51, 0.73) | NA (NA, NA) | 0.52 (0.5, 0.55) | 0.54 (0.52, 0.59) | 0.5 (0.5, 0.5) | 0.53 (0.5, 0.57) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.01 (0, 0.019) | 0 (0, 0.02) | 0 (0, 0.012) | 0.008 (0, 0.018) | 0 (0, 0.017) | 0 (0, 0.018) | 0 (0, 0.027) | 0 (0, 0.023) | 0 (0, 0.016) | 0 (0, 0) | 0 (0, 0.017) | 0 (0, 0.013) | 0 (0, 0.014) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| HRD+ | TC1 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| HRD+ | TC1 | time | 55 (51, 59) | 55 (51, 59) | 55 (51, 59) | 55 (51, 59) | 55 (51, 59) | 55 (51, 59) | 55 (51, 59) | 55 (51, 59) | ||||||||
| HRD+ | TC1 | n | 30 (30, 30) | 0 (0, 0) | 16 (15, 16) | 2 (1, 3) | 0 (0, 0) | 5 (4, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | post_p | 0.8 (0.73, 0.88) | NA (NA, NA) | 0.83 (0.74, 0.92) | 0.57 (0.55, 0.6) | NA (NA, NA) | 0.58 (0.52, 0.65) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | rate | 0.013 (0.009, 0.017) | NA (NA, NA) | 0.01 (0.005, 0.015) | 0.007 (0.001, 0.013) | NA (NA, NA) | 0.026 (0.018, 0.035) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| HRD+ | TC2 | time | 49 (45, 58) | 49 (45, 58) | 49 (45, 58) | 49 (45, 58) | 49 (45, 58) | 49 (45, 58) | 49 (45, 58) | 49 (45, 58) | ||||||||
| HRD+ | TC2 | n | 28 (26, 30) | 0 (0, 0) | 12 (10, 17) | 2 (0, 4) | 0 (0, 2) | 6 (4, 7) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | post_p | 0.91 (0.85, 0.98) | NA (NA, NA) | 0.8 (0.69, 0.91) | 0.59 (0.58, 0.59) | NA (NA, NA) | 0.59 (0.56, 0.65) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | rate | 0.014 (0.011, 0.015) | NA (NA, NA) | 0.01 (0.01, 0.021) | 0.005 (0.001, 0.009) | 0.107 (0.107, 0.107) | 0.011 (0.009, 0.015) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC3 | count | 321 | 321 | 321 | 321 | 321 | 321 | 321 | 321 | ||||||||
| HRD+ | TC3 | time | 45 (37, 55) | 45 (37, 55) | 45 (37, 55) | 45 (37, 55) | 45 (37, 55) | 45 (37, 55) | 45 (37, 55) | 45 (37, 55) | ||||||||
| HRD+ | TC3 | n | 27 (20, 36) | 0 (0, 0) | 18 (10, 25) | 3 (1, 6) | 1 (0, 2) | 5 (2, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC3 | post_p | 0.94 (0.78, 1) | NA (NA, NA) | 0.87 (0.71, 0.99) | 0.56 (0.51, 0.71) | 0.54 (0.5, 0.58) | 0.59 (0.52, 0.78) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC3 | r_prob | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC3 | rate | 0.008 (0.004, 0.014) | 0 (0, 0) | 0.007 (0.003, 0.014) | 0 (0, 0.023) | 0 (0, 0.035) | 0.006 (0, 0.019) | 0.019 (0.004, 0.034) | 0.01 (0, 0.169) | ||||||||
| HRD+ | TC4 | count | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | ||||||||
| HRD+ | TC4 | time | 50 (41, 58) | 50 (41, 58) | 50 (41, 58) | 50 (41, 58) | 50 (41, 58) | 50 (41, 58) | 50 (41, 58) | 50 (41, 58) | ||||||||
| HRD+ | TC4 | n | 26 (18, 30) | 0 (0, 0) | 17 (10, 25) | 5 (1, 7) | 1 (0, 2) | 6 (3, 9) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC4 | post_p | 0.82 (0.73, 0.94) | NA (NA, NA) | 0.82 (0.71, 0.94) | 0.56 (0.51, 0.64) | 0.53 (0.52, 0.56) | 0.59 (0.53, 0.77) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC4 | rate | 0.012 (0.007, 0.02) | NA (NA, NA) | 0.011 (0.004, 0.019) | 0.011 (0, 0.022) | 0 (0, 0.018) | 0.014 (0.008, 0.028) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||
| TP53+ | TC1 | time | 26 (23, 55) | 26 (23, 55) | 26 (23, 55) | 26 (23, 55) | 26 (23, 55) | 26 (23, 55) | 26 (23, 55) | 26 (23, 55) | ||||||||
| TP53+ | TC1 | n | 27 (20, 39) | 16 (10, 38) | 22 (6, 33) | 10 (3, 34) | 0 (0, 0) | 3 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | post_p | 0.75 (0.72, 0.83) | 0.72 (0.53, 0.89) | 0.76 (0.53, 0.94) | 0.71 (0.55, 0.83) | 0.63 (0.63, 0.63) | 0.53 (0.52, 0.68) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | rate | 0.016 (0.007, 0.022) | 0.013 (0.006, 0.019) | 0.011 (0, 0.023) | 0 (0, 0.015) | 0 (0, 0) | 0.013 (0, 0.024) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| TP53+ | TC2 | time | 48 (45, 54) | 48 (45, 54) | 48 (45, 54) | 48 (45, 54) | 48 (45, 54) | 48 (45, 54) | 48 (45, 54) | 48 (45, 54) | ||||||||
| TP53+ | TC2 | n | 35 (30, 42) | 33 (27, 34) | 22 (12, 33) | 15 (11, 21) | 0 (0, 0) | 5 (3, 7) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | post_p | 0.86 (0.74, 0.95) | 0.71 (0.71, 0.79) | 0.71 (0.58, 0.77) | 0.81 (0.66, 0.95) | NA (NA, NA) | 0.51 (0.51, 0.56) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | rate | 0.02 (0.016, 0.02) | 0.018 (0.013, 0.019) | 0.018 (0.017, 0.026) | 0.015 (0.011, 0.019) | NA (NA, NA) | 0.014 (0.012, 0.018) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | count | 49 | 49 | 49 | 49 | 49 | 49 | 49 | 49 | ||||||||
| TP53+ | TC3 | time | 35 (24, 53) | 35 (24, 53) | 35 (24, 53) | 35 (24, 53) | 35 (24, 53) | 35 (24, 53) | 35 (24, 53) | 35 (24, 53) | ||||||||
| TP53+ | TC3 | n | 24 (16, 50) | 19 (8, 35) | 12 (6, 34) | 10 (6, 20) | 0 (0, 2) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC3 | post_p | 0.76 (0.71, 0.92) | 0.75 (0.56, 0.89) | 0.73 (0.52, 0.95) | 0.73 (0.53, 0.87) | 0.54 (0.51, 0.57) | 0.55 (0.51, 0.69) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC3 | rate | 0.013 (0.005, 0.019) | 0.013 (0, 0.02) | 0.014 (0, 0.023) | 0.015 (0, 0.023) | 0 (0, 0.028) | 0 (0, 0.014) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | count | 26 | 26 | 26 | 26 | 26 | 26 | 26 | 26 | ||||||||
| TP53+ | TC4 | time | 36 (23, 56) | 36 (23, 56) | 36 (23, 56) | 36 (23, 56) | 36 (23, 56) | 36 (23, 56) | 36 (23, 56) | 36 (23, 56) | ||||||||
| TP53+ | TC4 | n | 31 (21, 61) | 20 (13, 42) | 10 (6, 36) | 10 (6, 27) | 0 (0, 2) | 4 (2, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | post_p | 0.8 (0.74, 0.91) | 0.77 (0.72, 0.9) | 0.72 (0.52, 0.86) | 0.68 (0.55, 0.82) | 0.52 (0.51, 0.55) | 0.56 (0.51, 0.72) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC4 | rate | 0.012 (0.009, 0.018) | 0.013 (0.004, 0.019) | 0.013 (0, 0.022) | 0.015 (0, 0.022) | 0 (0, 0.028) | 0 (0, 0.021) | NA (NA, NA) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||
| TEfus+ | TC1 | time | 28 (25, 38) | 28 (25, 38) | 28 (25, 38) | 28 (25, 38) | 28 (25, 38) | 28 (25, 38) | 28 (25, 38) | 28 (25, 38) | ||||||||
| TEfus+ | TC1 | n | 3 (2, 4) | 22 (11, 24) | 12 (8, 19) | 10 (7, 16) | 8 (4, 10) | 2 (1, 3) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | post_p | 0.53 (0.51, 0.61) | 0.75 (0.62, 0.84) | 0.73 (0.55, 0.9) | 0.63 (0.52, 0.73) | 0.56 (0.52, 0.66) | 0.55 (0.5, 0.59) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | rate | 0.009 (0, 0.034) | 0.016 (0.006, 0.025) | 0.007 (0.006, 0.016) | 0.018 (0.003, 0.022) | 0.01 (0, 0.014) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC2 | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | ||||||||
| TEfus+ | TC2 | time | 36 (33, 47) | 36 (33, 47) | 36 (33, 47) | 36 (33, 47) | 36 (33, 47) | 36 (33, 47) | 36 (33, 47) | 36 (33, 47) | ||||||||
| TEfus+ | TC2 | n | 5 (5, 6) | 30 (13, 34) | 23 (16, 35) | 21 (9, 27) | 9 (8, 10) | 1 (0, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | post_p | 0.55 (0.51, 0.63) | 0.76 (0.74, 0.96) | 0.78 (0.74, 0.86) | 0.72 (0.53, 0.81) | 0.57 (0.52, 0.63) | 0.58 (0.57, 0.64) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | rate | 0.019 (0.011, 0.029) | 0.016 (0.01, 0.019) | 0.014 (0.007, 0.02) | 0.015 (0.011, 0.026) | 0.012 (0.005, 0.018) | 0 (0, 0.009) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC3 | count | 52 | 52 | 52 | 52 | 52 | 52 | 52 | 52 | ||||||||
| TEfus+ | TC3 | time | 41 (30, 54) | 41 (30, 54) | 41 (30, 54) | 41 (30, 54) | 41 (30, 54) | 41 (30, 54) | 41 (30, 54) | 41 (30, 54) | ||||||||
| TEfus+ | TC3 | n | 4 (1, 8) | 25 (17, 45) | 18 (8, 38) | 14 (8, 22) | 15 (8, 22) | 2 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC3 | post_p | 0.6 (0.51, 0.75) | 0.8 (0.71, 0.92) | 0.75 (0.54, 0.95) | 0.72 (0.57, 0.86) | 0.79 (0.6, 0.97) | 0.56 (0.52, 0.66) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC3 | rate | 0.009 (0, 0.026) | 0.014 (0.007, 0.02) | 0.014 (0.008, 0.021) | 0.013 (0, 0.02) | 0.007 (0, 0.016) | 0 (0, 0.026) | NA (NA, NA) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | count | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | ||||||||
| TEfus+ | TC4 | time | 28 (24, 48) | 28 (24, 48) | 28 (24, 48) | 28 (24, 48) | 28 (24, 48) | 28 (24, 48) | 28 (24, 48) | 28 (24, 48) | ||||||||
| TEfus+ | TC4 | n | 4 (1, 8) | 26 (21, 37) | 12 (5, 29) | 11 (7, 18) | 7 (5, 15) | 2 (1, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | post_p | 0.55 (0.51, 0.73) | 0.83 (0.7, 0.97) | 0.74 (0.51, 0.84) | 0.71 (0.56, 0.83) | 0.59 (0.51, 0.87) | 0.53 (0.51, 0.56) | NA (NA, NA) | 0.53 (0.53, 0.53) | ||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC4 | rate | 0 (0, 0.021) | 0.012 (0.006, 0.016) | 0.011 (0, 0.02) | 0.012 (0.005, 0.016) | 0.008 (0, 0.018) | 0 (0, 0.024) | NA (NA, NA) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| PI3K+ | TC1 | time | 32 (27, 38) | 32 (27, 38) | 32 (27, 38) | 32 (27, 38) | 32 (27, 38) | 32 (27, 38) | 32 (27, 38) | 32 (27, 38) | ||||||||
| PI3K+ | TC1 | n | 14 (11, 18) | 23 (22, 25) | 13 (7, 19) | 12 (8, 13) | 0 (0, 0) | 1 (1, 2) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | post_p | 0.7 (0.65, 0.74) | 0.74 (0.73, 0.77) | 0.82 (0.67, 0.84) | 0.75 (0.61, 0.76) | NA (NA, NA) | 0.54 (0.53, 0.55) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | r_prob | 0.27 (0.27, 0.27) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | rate | 0.013 (0.01, 0.014) | 0.018 (0.01, 0.018) | 0.012 (0.012, 0.013) | 0.012 (0.002, 0.015) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| PI3K+ | TC2 | time | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | 33 (33, 33) | ||||||||
| PI3K+ | TC2 | n | 6 (6, 6) | 29 (29, 29) | 17 (17, 17) | 8 (8, 8) | 0 (0, 0) | 2 (2, 2) | 5 (5, 5) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | post_p | 0.63 (0.63, 0.63) | 0.86 (0.86, 0.86) | 0.76 (0.76, 0.76) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.51 (0.51, 0.51) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | r_prob | 0.07 (0.07, 0.07) | 0.27 (0.27, 0.27) | 0.27 (0.27, 0.27) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | rate | 0.013 (0.013, 0.013) | 0.009 (0.009, 0.009) | 0.012 (0.012, 0.012) | 0.022 (0.022, 0.022) | NA (NA, NA) | 0.194 (0.194, 0.194) | 0.016 (0.016, 0.016) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | count | 44 | 44 | 44 | 44 | 44 | 44 | 44 | 44 | ||||||||
| PI3K+ | TC3 | time | 39 (26, 55) | 39 (26, 55) | 39 (26, 55) | 39 (26, 55) | 39 (26, 55) | 39 (26, 55) | 39 (26, 55) | 39 (26, 55) | ||||||||
| PI3K+ | TC3 | n | 17 (7, 34) | 23 (15, 36) | 18 (10, 32) | 13 (6, 21) | 0 (0, 0) | 2 (0, 6) | 4 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC3 | post_p | 0.75 (0.54, 0.92) | 0.8 (0.71, 0.92) | 0.79 (0.62, 0.93) | 0.73 (0.52, 0.92) | NA (NA, NA) | 0.54 (0.5, 0.7) | 0.57 (0.51, 0.69) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC3 | rate | 0.012 (0.002, 0.018) | 0.012 (0.002, 0.019) | 0.014 (0.001, 0.019) | 0.013 (0, 0.022) | 0 (0, 0) | 0 (0, 0.026) | 0 (0, 0.021) | NA (NA, NA) | ||||||||
| PI3K+ | TC4 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||
| PI3K+ | TC4 | time | 45 (27, 56) | 45 (27, 56) | 45 (27, 56) | 45 (27, 56) | 45 (27, 56) | 45 (27, 56) | 45 (27, 56) | 45 (27, 56) | ||||||||
| PI3K+ | TC4 | n | 17 (8, 25) | 28 (23, 51) | 27 (16, 33) | 15 (7, 23) | 0 (0, 0) | 3 (1, 7) | 4 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC4 | post_p | 0.73 (0.65, 0.84) | 0.87 (0.73, 0.99) | 0.82 (0.71, 0.9) | 0.76 (0.62, 0.89) | NA (NA, NA) | 0.54 (0.52, 0.61) | 0.55 (0.52, 0.66) | NA (NA, NA) | ||||||||
| PI3K+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.31 (0.31, 0.31) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC4 | rate | 0.015 (0.013, 0.017) | 0.013 (0.008, 0.022) | 0.014 (0.006, 0.021) | 0.013 (0.009, 0.02) | NA (NA, NA) | 0 (0, 0.023) | 0.011 (0, 0.017) | NA (NA, NA) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 |
| all | TC1 | time | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) | 41 (22, 53) |
| all | TC1 | n | 35 (24, 94) | 11 (6, 19) | 4 (2, 8) | 15 (8, 30) | 15 (9, 37) | 8 (5, 24) | 11 (8, 23) | 8 (4, 15) | 8 (5, 16) | 0 (0, 0) | 6 (4, 11) | 1 (0, 4) | 0 (0, 1) | 3 (0, 4) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.15 (0.05, 0.44) | 0.36 (0.22, 0.46) | 0.41 (0.22, 0.49) | 0.29 (0.09, 0.45) | 0.28 (0.1, 0.48) | 0.35 (0.1, 0.47) | 0.36 (0.18, 0.47) | 0.3 (0.18, 0.41) | 0.4 (0.15, 0.49) | NA (NA, NA) | 0.33 (0.12, 0.48) | 0.45 (0.41, 0.49) | 0.48 (0.42, 0.49) | 0.44 (0.34, 0.47) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.27 (0.27, 0.27) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.029 (0.022, 0.034) | 0.03 (0.024, 0.042) | 0.033 (0.018, 0.105) | 0.027 (0.019, 0.041) | 0.027 (0.021, 0.046) | 0.028 (0.022, 0.067) | 0.026 (0.016, 0.032) | 0.036 (0.026, 0.07) | 0.025 (0.018, 0.093) | NA (NA, NA) | 0.032 (0.022, 0.078) | 0.031 (0, 0.463) | 0.022 (0, 0.064) | 0.051 (0.019, 0.205) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 | 24 |
| all | TC2 | time | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) | 38 (11, 56) |
| all | TC2 | n | 30 (17, 91) | 10 (2, 18) | 4 (1, 9) | 15 (7, 21) | 14 (10, 26) | 9 (5, 21) | 10 (5, 22) | 9 (4, 15) | 6 (2, 17) | 0 (0, 0) | 5 (2, 12) | 2 (0, 5) | 0 (0, 1) | 1 (0, 4) | 0 (0, 0) | 0 (0, 1) |
| all | TC2 | post_p | 0.29 (0.12, 0.45) | 0.34 (0.17, 0.49) | 0.43 (0.22, 0.48) | 0.37 (0.15, 0.45) | 0.34 (0.09, 0.46) | 0.29 (0.13, 0.47) | 0.31 (0.15, 0.45) | 0.37 (0.22, 0.48) | 0.38 (0.19, 0.45) | NA (NA, NA) | 0.42 (0.16, 0.49) | 0.46 (0.38, 0.49) | 0.43 (0.43, 0.43) | 0.45 (0.3, 0.5) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.027 (0.022, 0.033) | 0.033 (0.014, 0.049) | 0.027 (0, 0.051) | 0.03 (0.021, 0.037) | 0.03 (0.016, 0.037) | 0.028 (0.018, 0.054) | 0.031 (0.023, 0.047) | 0.026 (0.017, 0.042) | 0.029 (0.016, 0.069) | NA (NA, NA) | 0.028 (0, 0.078) | 0.029 (0, 0.08) | 0.019 (0, 0.04) | 0.034 (0, 0.104) | NA (NA, NA) | 0 (0, 0) |
| all | TC4 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| all | TC4 | time | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) | 40 (40, 40) |
| all | TC4 | n | 12 (12, 12) | 7 (7, 7) | 7 (7, 7) | 25 (25, 25) | 9 (9, 9) | 18 (18, 18) | 19 (19, 19) | 4 (4, 4) | 16 (16, 16) | 0 (0, 0) | 10 (10, 10) | 3 (3, 3) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.09 (0.09, 0.09) | 0.31 (0.31, 0.31) | 0.11 (0.11, 0.11) | 0.41 (0.41, 0.41) | 0.23 (0.23, 0.23) | 0.49 (0.49, 0.49) | 0.41 (0.41, 0.41) | 0.06 (0.06, 0.06) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.43 (0.43, 0.43) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.26 (0.26, 0.26) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.047 (0.047, 0.047) | 0.037 (0.037, 0.037) | 0.048 (0.048, 0.048) | 0.024 (0.024, 0.024) | 0.032 (0.032, 0.032) | 0.021 (0.021, 0.021) | 0.025 (0.025, 0.025) | 0.081 (0.081, 0.081) | 0.016 (0.016, 0.016) | NA (NA, NA) | 0.016 (0.016, 0.016) | 0.02 (0.02, 0.02) | NA (NA, NA) | 0.091 (0.091, 0.091) | NA (NA, NA) | NA (NA, NA) |
| HRD+ | TC1 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||
| HRD+ | TC1 | time | 56 (53, 59) | 56 (53, 59) | 56 (53, 59) | 56 (53, 59) | 56 (53, 59) | 56 (53, 59) | 56 (53, 59) | 56 (53, 59) | ||||||||
| HRD+ | TC1 | n | 26 (11, 34) | 0 (0, 0) | 18 (12, 28) | 5 (2, 8) | 0 (0, 1) | 4 (3, 7) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | post_p | 0.28 (0.12, 0.42) | NA (NA, NA) | 0.28 (0.15, 0.48) | 0.42 (0.37, 0.48) | 0.45 (0.45, 0.45) | 0.42 (0.39, 0.46) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | rate | 0.026 (0.019, 0.033) | NA (NA, NA) | 0.027 (0.022, 0.038) | 0.037 (0.027, 0.052) | 0.018 (0.004, 0.049) | 0.025 (0.019, 0.037) | NA (NA, NA) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | ||||||||
| HRD+ | TC2 | time | 58 (52, 60) | 58 (52, 60) | 58 (52, 60) | 58 (52, 60) | 58 (52, 60) | 58 (52, 60) | 58 (52, 60) | 58 (52, 60) | ||||||||
| HRD+ | TC2 | n | 27 (18, 31) | 0 (0, 0) | 20 (12, 27) | 4 (2, 6) | 0 (0, 0) | 4 (3, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | post_p | 0.26 (0.18, 0.38) | NA (NA, NA) | 0.32 (0.3, 0.37) | 0.43 (0.33, 0.45) | NA (NA, NA) | 0.45 (0.38, 0.48) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | rate | 0.022 (0.019, 0.034) | NA (NA, NA) | 0.023 (0.02, 0.035) | 0.026 (0.022, 0.042) | 0.141 (0.141, 0.141) | 0.023 (0.016, 0.038) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||||||||
| HRD+ | TC4 | time | 57 (52, 60) | 57 (52, 60) | 57 (52, 60) | 57 (52, 60) | 57 (52, 60) | 57 (52, 60) | 57 (52, 60) | 57 (52, 60) | ||||||||
| HRD+ | TC4 | n | 26 (20, 36) | 0 (0, 0) | 14 (7, 24) | 4 (3, 7) | 0 (0, 3) | 6 (4, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC4 | post_p | 0.44 (0.4, 0.49) | NA (NA, NA) | 0.22 (0.18, 0.4) | 0.43 (0.32, 0.48) | 0.45 (0.45, 0.45) | 0.39 (0.19, 0.45) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC4 | rate | 0.02 (0.018, 0.027) | 0 (0, 0) | 0.03 (0.019, 0.037) | 0.026 (0.02, 0.038) | 0.037 (0.02, 0.053) | 0.032 (0.023, 0.064) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | count | 106 | 106 | 106 | 106 | 106 | 106 | 106 | 106 | ||||||||
| TP53+ | TC1 | time | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | ||||||||
| TP53+ | TC1 | n | 21 (11, 39) | 14 (8, 24) | 12 (7, 26) | 11 (5, 25) | 0 (0, 2) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | post_p | 0.33 (0.07, 0.48) | 0.32 (0.13, 0.47) | 0.3 (0.12, 0.46) | 0.38 (0.16, 0.48) | 0.46 (0.41, 0.49) | 0.44 (0.33, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | rate | 0.025 (0.019, 0.04) | 0.027 (0.021, 0.045) | 0.03 (0.02, 0.05) | 0.028 (0.021, 0.045) | 0.026 (0, 0.091) | 0.035 (0.011, 0.083) | 0 (0, 0) | 0 (0, 0.026) | ||||||||
| TP53+ | TC2 | count | 140 | 140 | 140 | 140 | 140 | 140 | 140 | 140 | ||||||||
| TP53+ | TC2 | time | 34 (21, 52) | 34 (21, 52) | 34 (21, 52) | 34 (21, 52) | 34 (21, 52) | 34 (21, 52) | 34 (21, 52) | 34 (21, 52) | ||||||||
| TP53+ | TC2 | n | 20 (12, 37) | 14 (7, 30) | 14 (9, 24) | 10 (6, 20) | 0 (0, 1) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | post_p | 0.33 (0.08, 0.48) | 0.32 (0.12, 0.48) | 0.38 (0.11, 0.48) | 0.37 (0.17, 0.48) | 0.47 (0.42, 0.5) | 0.45 (0.32, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | rate | 0.026 (0.018, 0.037) | 0.026 (0.018, 0.045) | 0.027 (0.016, 0.04) | 0.027 (0.018, 0.043) | 0 (0, 0.089) | 0.032 (0, 0.096) | NA (NA, NA) | 0.023 (0, 0.202) | ||||||||
| TP53+ | TC3 | count | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | ||||||||
| TP53+ | TC3 | time | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | 41 (29, 56) | ||||||||
| TP53+ | TC3 | n | 19 (11, 49) | 17 (8, 35) | 12 (10, 20) | 8 (5, 12) | 0 (0, 2) | 3 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC3 | post_p | 0.32 (0.16, 0.44) | 0.39 (0.19, 0.48) | 0.34 (0.2, 0.47) | 0.34 (0.16, 0.46) | 0.48 (0.48, 0.48) | 0.48 (0.44, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC3 | rate | 0.027 (0.021, 0.036) | 0.026 (0.02, 0.034) | 0.027 (0.02, 0.036) | 0.032 (0.027, 0.078) | 0 (0, 0.04) | 0.018 (0, 0.042) | 0 (0, 0) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | count | 47 | 47 | 47 | 47 | 47 | 47 | 47 | 47 | ||||||||
| TP53+ | TC4 | time | 35 (27, 56) | 35 (27, 56) | 35 (27, 56) | 35 (27, 56) | 35 (27, 56) | 35 (27, 56) | 35 (27, 56) | 35 (27, 56) | ||||||||
| TP53+ | TC4 | n | 20 (10, 38) | 14 (9, 18) | 12 (5, 27) | 11 (6, 18) | 0 (0, 1) | 4 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | post_p | 0.36 (0.17, 0.47) | 0.34 (0.14, 0.47) | 0.42 (0.21, 0.48) | 0.35 (0.17, 0.47) | 0.47 (0.42, 0.49) | 0.45 (0.34, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC4 | rate | 0.027 (0.018, 0.044) | 0.026 (0.019, 0.043) | 0.025 (0.02, 0.05) | 0.027 (0.018, 0.044) | 0 (0, 0.072) | 0.031 (0.014, 0.1) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC1 | count | 83 | 83 | 83 | 83 | 83 | 83 | 83 | 83 | ||||||||
| TEfus+ | TC1 | time | 42 (32, 57) | 42 (32, 57) | 42 (32, 57) | 42 (32, 57) | 42 (32, 57) | 42 (32, 57) | 42 (32, 57) | 42 (32, 57) | ||||||||
| TEfus+ | TC1 | n | 5 (2, 8) | 20 (10, 39) | 14 (8, 29) | 11 (5, 21) | 8 (5, 17) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | post_p | 0.41 (0.21, 0.49) | 0.35 (0.12, 0.48) | 0.34 (0.13, 0.48) | 0.32 (0.14, 0.45) | 0.36 (0.19, 0.48) | 0.45 (0.33, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | rate | 0.036 (0.016, 0.099) | 0.025 (0.019, 0.038) | 0.028 (0.021, 0.041) | 0.03 (0.022, 0.047) | 0.028 (0.02, 0.049) | 0.032 (0.012, 0.071) | NA (NA, NA) | 0.039 (0.039, 0.039) | ||||||||
| TEfus+ | TC2 | count | 93 | 93 | 93 | 93 | 93 | 93 | 93 | 93 | ||||||||
| TEfus+ | TC2 | time | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | 40 (29, 56) | ||||||||
| TEfus+ | TC2 | n | 5 (3, 9) | 18 (10, 35) | 15 (9, 28) | 11 (6, 19) | 9 (4, 14) | 2 (0, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | post_p | 0.42 (0.26, 0.49) | 0.28 (0.11, 0.47) | 0.26 (0.11, 0.46) | 0.34 (0.14, 0.47) | 0.38 (0.18, 0.48) | 0.45 (0.36, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | rate | 0.029 (0.018, 0.064) | 0.027 (0.019, 0.043) | 0.027 (0.019, 0.041) | 0.03 (0.02, 0.044) | 0.029 (0.019, 0.061) | 0.036 (0, 0.086) | NA (NA, NA) | 0 (0, 0.137) | ||||||||
| TEfus+ | TC3 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| TEfus+ | TC3 | time | 38 (34, 41) | 38 (34, 41) | 38 (34, 41) | 38 (34, 41) | 38 (34, 41) | 38 (34, 41) | 38 (34, 41) | 38 (34, 41) | ||||||||
| TEfus+ | TC3 | n | 4 (3, 6) | 18 (16, 19) | 14 (11, 18) | 16 (7, 24) | 11 (10, 12) | 2 (2, 3) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC3 | post_p | 0.44 (0.41, 0.46) | 0.3 (0.25, 0.36) | 0.28 (0.2, 0.36) | 0.44 (0.39, 0.48) | 0.42 (0.38, 0.46) | 0.44 (0.44, 0.44) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC3 | rate | 0.027 (0.025, 0.03) | 0.025 (0.025, 0.025) | 0.027 (0.024, 0.031) | 0.03 (0.027, 0.033) | 0.017 (0.015, 0.02) | 0.013 (0.003, 0.023) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | count | 29 | 29 | 29 | 29 | 29 | 29 | 29 | 29 | ||||||||
| TEfus+ | TC4 | time | 39 (30, 57) | 39 (30, 57) | 39 (30, 57) | 39 (30, 57) | 39 (30, 57) | 39 (30, 57) | 39 (30, 57) | 39 (30, 57) | ||||||||
| TEfus+ | TC4 | n | 4 (1, 8) | 21 (13, 36) | 14 (8, 21) | 12 (6, 19) | 9 (4, 15) | 3 (0, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | post_p | 0.43 (0.21, 0.48) | 0.36 (0.21, 0.47) | 0.37 (0.17, 0.45) | 0.39 (0.23, 0.47) | 0.37 (0.15, 0.48) | 0.45 (0.32, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC4 | rate | 0.032 (0.022, 0.112) | 0.023 (0.021, 0.034) | 0.027 (0.021, 0.036) | 0.026 (0.019, 0.042) | 0.027 (0.015, 0.039) | 0.034 (0.007, 0.09) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | count | 73 | 73 | 73 | 73 | 73 | 73 | 73 | 73 | ||||||||
| PI3K+ | TC1 | time | 44 (30, 57) | 44 (30, 57) | 44 (30, 57) | 44 (30, 57) | 44 (30, 57) | 44 (30, 57) | 44 (30, 57) | 44 (30, 57) | ||||||||
| PI3K+ | TC1 | n | 13 (7, 22) | 19 (9, 36) | 15 (8, 25) | 10 (6, 22) | 0 (0, 0) | 3 (1, 6) | 3 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | post_p | 0.33 (0.11, 0.46) | 0.35 (0.14, 0.47) | 0.32 (0.1, 0.47) | 0.32 (0.13, 0.46) | NA (NA, NA) | 0.45 (0.33, 0.49) | 0.45 (0.29, 0.49) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | r_prob | 0.27 (0.27, 0.27) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | rate | 0.029 (0.021, 0.043) | 0.026 (0.021, 0.04) | 0.026 (0.02, 0.043) | 0.03 (0.02, 0.052) | NA (NA, NA) | 0.033 (0.011, 0.083) | 0.033 (0.015, 0.075) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | count | 97 | 97 | 97 | 97 | 97 | 97 | 97 | 97 | ||||||||
| PI3K+ | TC2 | time | 39 (28, 57) | 39 (28, 57) | 39 (28, 57) | 39 (28, 57) | 39 (28, 57) | 39 (28, 57) | 39 (28, 57) | 39 (28, 57) | ||||||||
| PI3K+ | TC2 | n | 14 (7, 28) | 18 (10, 29) | 14 (9, 29) | 11 (6, 20) | 0 (0, 0) | 2 (0, 5) | 3 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | post_p | 0.35 (0.12, 0.47) | 0.32 (0.11, 0.48) | 0.32 (0.11, 0.47) | 0.34 (0.13, 0.47) | NA (NA, NA) | 0.45 (0.36, 0.49) | 0.45 (0.29, 0.5) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | r_prob | 0.07 (0.07, 0.07) | 0.27 (0.27, 0.27) | 0.27 (0.27, 0.27) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | rate | 0.028 (0.02, 0.047) | 0.028 (0.02, 0.04) | 0.027 (0.02, 0.043) | 0.028 (0.021, 0.045) | 0.299 (0.299, 0.299) | 0.034 (0, 0.088) | 0.029 (0, 0.088) | 0 (0, 0.037) | ||||||||
| PI3K+ | TC3 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| PI3K+ | TC3 | time | 46 (44, 48) | 46 (44, 48) | 46 (44, 48) | 46 (44, 48) | 46 (44, 48) | 46 (44, 48) | 46 (44, 48) | 46 (44, 48) | ||||||||
| PI3K+ | TC3 | n | 16 (14, 18) | 17 (11, 23) | 19 (17, 21) | 15 (10, 20) | 0 (0, 0) | 1 (0, 2) | 2 (1, 2) | 0 (0, 0) | ||||||||
| PI3K+ | TC3 | post_p | 0.35 (0.33, 0.37) | 0.22 (0.13, 0.31) | 0.34 (0.3, 0.37) | 0.35 (0.24, 0.47) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.43 (0.41, 0.45) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC3 | rate | 0.023 (0.02, 0.026) | 0.033 (0.029, 0.037) | 0.025 (0.022, 0.029) | 0.027 (0.026, 0.028) | NA (NA, NA) | 0.031 (0.031, 0.031) | 0.049 (0.038, 0.061) | NA (NA, NA) | ||||||||
| PI3K+ | TC4 | count | 54 | 54 | 54 | 54 | 54 | 54 | 54 | 54 | ||||||||
| PI3K+ | TC4 | time | 32 (23, 48) | 32 (23, 48) | 32 (23, 48) | 32 (23, 48) | 32 (23, 48) | 32 (23, 48) | 32 (23, 48) | 32 (23, 48) | ||||||||
| PI3K+ | TC4 | n | 11 (6, 18) | 17 (11, 27) | 14 (9, 24) | 10 (6, 16) | 0 (0, 0) | 2 (0, 5) | 3 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC4 | post_p | 0.38 (0.19, 0.48) | 0.37 (0.14, 0.49) | 0.35 (0.16, 0.46) | 0.38 (0.2, 0.48) | NA (NA, NA) | 0.44 (0.35, 0.49) | 0.43 (0.31, 0.49) | NA (NA, NA) | ||||||||
| PI3K+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.31 (0.31, 0.31) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC4 | rate | 0.027 (0.016, 0.048) | 0.025 (0.019, 0.04) | 0.026 (0.019, 0.038) | 0.026 (0.018, 0.046) | NA (NA, NA) | 0.031 (0, 0.135) | 0.028 (0, 0.089) | NA (NA, NA) |