Simulation scenario 4, HS phase

Setting description

TC3 more effective in the HRD+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.022, shape = 1.3	scale = 0.024, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 41.8, median = 34.2	mean = 39, median = 31.9
all	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.07, hr = 0.91	af = 1, hr = 1
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
HRD+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.023, shape = 1.3	scale = 0.024, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39.9, median = 32.6	mean = 39, median = 31.9
TP53+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.02, hr = 0.97	af = 1, hr = 1
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.022, shape = 1.3	scale = 0.024, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 42.7, median = 34.8	mean = 39, median = 31.9
TEfus+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.09, hr = 0.89	af = 1, hr = 1
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.023, shape = 1.3	scale = 0.024, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 40.5, median = 33.1	mean = 39, median = 31.9
PI3K+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1.04, hr = 0.95	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
—-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
—+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
–+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
–++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 39, median = 31.9	mean = 39, median = 31.9
-+++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+—	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+–+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+–+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+-+-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+-++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+-++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
++–	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
++–	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
++-+	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
++-+	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
+++-	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
+++-	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1
++++	param	scale = 0.024, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.027, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.024, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 34.3, median = 28	mean = 34.3, median = 28	mean = 78.1, median = 63.8	mean = 39, median = 31.9
++++	effect	af = 1, hr = 1	af = 0.88, hr = 1.18	af = 0.88, hr = 1.18	af = 2, hr = 0.41	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 6 3 73 26 HRD+ 2 3 321 21 TP53+ 9 3 49 26 TEfus+ 6 7 52 21 PI3K+ 3 1 44 13

TC1 TC2 TC3 TC4 all 0.012 0.006 0.146 0.052 HRD+ 0.004 0.006 0.642 0.042 TP53+ 0.018 0.006 0.098 0.052 TEfus+ 0.012 0.014 0.104 0.042 PI3K+ 0.006 0.002 0.088 0.026

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 15 24 0 1 HRD+ 8 6 0 10 TP53+ 106 140 17 47 TEfus+ 83 93 2 29 PI3K+ 73 97 2 54

TC1 TC2 TC3 TC4 all 0.030 0.048 0.000 0.002 HRD+ 0.016 0.012 0.000 0.020 TP53+ 0.212 0.280 0.034 0.094 TEfus+ 0.166 0.186 0.004 0.058 PI3K+ 0.146 0.194 0.004 0.108

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.376	0.05	0.034	0.170	0.172
Error subgroup	0.492	0.05	0.034	0.334	0.172
Power signature	0.642	0.00	0.000	0.642	0.000
Power subgroup	0.812	0.00	0.000	0.812	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	6	3	73	26
all	futility	0	15	24	0	1
all	max_n	0	0	0	0	0
all	n	612 (562, 676)	263 (188, 354)	262 (181, 354)	328 (164, 428)	338 (233, 446)
all	n_unique	612 (562, 676)	263 (188, 354)	262 (181, 354)	328 (164, 428)	338 (233, 446)
all	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (28, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	30 (10, 53)	36 (11, 55)	20 (12, 49)	15 (12, 36)
all	post_p	NA (NA, NA)	0.28 (0.04, 0.75)	0.3 (0.04, 0.75)	0.99 (0.9, 1)	0.84 (0.38, 0.99)
all	rate	0.023 (0.022, 0.025)	0.025 (0.022, 0.028)	0.025 (0.023, 0.028)	0.018 (0.017, 0.02)	0.021 (0.019, 0.024)
HRD+	graduation	0	2	3	321	21
HRD+	futility	0	8	6	0	10
HRD+	max_n	0	0	0	0	0
HRD+	n	85 (71, 100)	38 (23, 57)	38 (24, 54)	52 (34, 72)	43 (27, 61)
HRD+	n_unique	85 (71, 100)	38 (23, 57)	38 (24, 54)	52 (34, 72)	43 (27, 61)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	51 (39, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	56 (50, 60)	58 (48, 60)	45 (37, 55)	53 (41, 59)
HRD+	post_p	NA (NA, NA)	0.36 (0.08, 0.8)	0.37 (0.07, 0.8)	1 (0.98, 1)	0.55 (0.15, 0.94)
HRD+	rate	0.023 (0.019, 0.028)	0.025 (0.019, 0.033)	0.024 (0.018, 0.033)	0.009 (0.007, 0.013)	0.022 (0.016, 0.029)
TP53+	graduation	0	9	3	49	26
TP53+	futility	0	106	140	17	47
TP53+	max_n	0	0	0	0	0
TP53+	n	228 (202, 260)	100 (55, 152)	102 (54, 149)	113 (51, 165)	125 (59, 178)
TP53+	n_unique	228 (202, 260)	100 (55, 152)	102 (54, 149)	113 (51, 165)	125 (59, 178)
TP53+	time_trial	60 (60, 60)	60 (40, 60)	60 (29, 60)	60 (47, 60)	60 (42, 60)
TP53+	time_stop	NA (NA, NA)	42 (28, 54)	35 (21, 52)	36 (24, 56)	35 (26, 57)
TP53+	post_p	NA (NA, NA)	0.36 (0.06, 0.8)	0.38 (0.05, 0.81)	0.82 (0.36, 0.98)	0.72 (0.25, 0.97)
TP53+	rate	0.023 (0.02, 0.026)	0.025 (0.021, 0.031)	0.025 (0.022, 0.031)	0.02 (0.017, 0.025)	0.021 (0.018, 0.026)
TEfus+	graduation	0	6	7	52	21
TEfus+	futility	0	83	93	2	29
TEfus+	max_n	0	0	0	0	0
TEfus+	n	197 (172, 224)	89 (56, 128)	90 (53, 137)	100 (50, 139)	109 (59, 151)
TEfus+	n_unique	197 (172, 224)	89 (56, 128)	90 (53, 137)	100 (50, 139)	109 (59, 151)
TEfus+	time_trial	60 (60, 60)	60 (44, 60)	60 (40, 60)	60 (56, 60)	60 (60, 60)
TEfus+	time_stop	NA (NA, NA)	42 (31, 56)	40 (29, 56)	41 (30, 54)	36 (25, 56)
TEfus+	post_p	NA (NA, NA)	0.36 (0.06, 0.81)	0.35 (0.06, 0.8)	0.94 (0.64, 1)	0.71 (0.2, 0.96)
TEfus+	rate	0.023 (0.02, 0.026)	0.025 (0.021, 0.031)	0.025 (0.021, 0.031)	0.018 (0.015, 0.021)	0.021 (0.018, 0.026)
PI3K+	graduation	0	3	1	44	13
PI3K+	futility	0	73	97	2	54
PI3K+	max_n	0	0	0	0	0
PI3K+	n	212 (187, 239)	100 (59, 142)	97 (54, 145)	105 (50, 146)	121 (57, 172)
PI3K+	n_unique	212 (187, 239)	100 (59, 142)	97 (54, 145)	105 (50, 146)	121 (57, 172)
PI3K+	time_trial	60 (60, 60)	60 (50, 60)	60 (41, 60)	60 (60, 60)	60 (44, 60)
PI3K+	time_stop	NA (NA, NA)	43 (30, 56)	39 (28, 57)	39 (26, 54)	33 (24, 53)
PI3K+	post_p	NA (NA, NA)	0.4 (0.07, 0.82)	0.37 (0.06, 0.79)	0.85 (0.42, 0.98)	0.73 (0.24, 0.97)
PI3K+	rate	0.023 (0.02, 0.026)	0.024 (0.021, 0.03)	0.025 (0.021, 0.031)	0.02 (0.016, 0.024)	0.022 (0.018, 0.026)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	6	3	73	26
—-	futility	0	15	24	0	1
—-	max_n	0	0	0	0	0
—-	n	190 (158, 224)	63 (28, 141)	60 (25, 134)	98 (25, 179)	104 (29, 181)
—-	n_unique	190 (158, 224)	63 (28, 141)	60 (25, 134)	98 (25, 179)	104 (29, 181)
—-	post_p	NA (NA, NA)	0.34 (0.06, 0.79)	0.32 (0.07, 0.78)	0.68 (0.21, 0.97)	0.67 (0.2, 0.96)
—-	rate	0.023 (0.02, 0.026)	0.027 (0.021, 0.035)	0.026 (0.021, 0.035)	0.021 (0.017, 0.028)	0.021 (0.017, 0.028)
—+	graduation	0	9	4	105	36
—+	futility	0	80	107	2	54
—+	max_n	0	0	0	0	0
—+	n	42 (33, 53)	19 (9, 37)	17 (8, 37)	20 (7, 41)	22 (9, 42)
—+	n_unique	42 (33, 53)	19 (9, 37)	17 (8, 37)	20 (7, 41)	22 (9, 42)
—+	post_p	NA (NA, NA)	0.42 (0.1, 0.81)	0.44 (0.11, 0.8)	0.6 (0.19, 0.92)	0.58 (0.17, 0.91)
—+	rate	0.023 (0.017, 0.03)	0.026 (0.017, 0.04)	0.025 (0.017, 0.042)	0.022 (0.013, 0.036)	0.022 (0.015, 0.036)
–+-	graduation	0	12	10	117	44
–+-	futility	0	89	104	2	29
–+-	max_n	0	0	0	0	0
–+-	n	12 (8, 19)	7 (3, 13)	7 (3, 13)	6 (2, 12)	6 (2, 13)
–+-	n_unique	12 (8, 19)	7 (3, 13)	7 (3, 13)	6 (2, 12)	6 (2, 13)
–+-	post_p	NA (NA, NA)	0.45 (0.17, 0.79)	0.45 (0.18, 0.75)	0.52 (0.24, 0.81)	0.51 (0.22, 0.8)
–+-	rate	0.023 (0.012, 0.036)	0.026 (0.012, 0.056)	0.025 (0.012, 0.053)	0.022 (0.008, 0.048)	0.024 (0.01, 0.055)
–++	graduation	0	14	11	140	53
–++	futility	0	135	159	4	75
–++	max_n	0	0	0	0	0
–++	n	66 (51, 79)	24 (10, 53)	23 (10, 57)	26 (9, 57)	32 (13, 65)
–++	n_unique	66 (51, 79)	24 (10, 53)	23 (10, 57)	26 (9, 57)	32 (13, 65)
–++	post_p	NA (NA, NA)	0.43 (0.09, 0.81)	0.38 (0.08, 0.81)	0.61 (0.17, 0.92)	0.58 (0.18, 0.93)
–++	rate	0.023 (0.018, 0.029)	0.026 (0.019, 0.038)	0.026 (0.019, 0.042)	0.022 (0.015, 0.036)	0.022 (0.016, 0.032)
-+–	graduation	0	15	5	111	48
-+–	futility	0	113	150	17	47
-+–	max_n	0	0	0	0	0
-+–	n	81 (65, 98)	30 (13, 68)	28 (14, 59)	33 (11, 76)	40 (13, 76)
-+–	n_unique	81 (65, 98)	30 (13, 68)	28 (14, 59)	33 (11, 76)	40 (13, 76)
-+–	post_p	NA (NA, NA)	0.42 (0.07, 0.83)	0.41 (0.08, 0.82)	0.61 (0.16, 0.94)	0.6 (0.19, 0.92)
-+–	rate	0.023 (0.019, 0.028)	0.026 (0.019, 0.038)	0.026 (0.019, 0.037)	0.022 (0.016, 0.033)	0.022 (0.016, 0.033)
-+-+	graduation	0	18	6	135	57
-+-+	futility	0	156	192	19	86
-+-+	max_n	0	0	0	0	0
-+-+	n	53 (42, 66)	20 (8, 47)	20 (9, 45)	22 (8, 47)	27 (11, 53)
-+-+	n_unique	53 (42, 66)	20 (8, 47)	20 (9, 45)	22 (8, 47)	27 (11, 53)
-+-+	post_p	NA (NA, NA)	0.42 (0.1, 0.84)	0.41 (0.09, 0.79)	0.59 (0.2, 0.91)	0.6 (0.18, 0.93)
-+-+	rate	0.023 (0.018, 0.029)	0.025 (0.017, 0.041)	0.026 (0.019, 0.04)	0.022 (0.014, 0.036)	0.021 (0.015, 0.033)
-++-	graduation	0	20	12	149	61
-++-	futility	0	163	206	19	71
-++-	max_n	0	0	0	0	0
-++-	n	47 (37, 59)	17 (8, 39)	18 (9, 40)	20 (7, 44)	23 (7, 47)
-++-	n_unique	47 (37, 59)	17 (8, 39)	18 (9, 40)	20 (7, 44)	23 (7, 47)
-++-	post_p	NA (NA, NA)	0.39 (0.09, 0.83)	0.39 (0.1, 0.79)	0.6 (0.19, 0.91)	0.59 (0.21, 0.93)
-++-	rate	0.023 (0.017, 0.03)	0.026 (0.018, 0.043)	0.026 (0.018, 0.04)	0.021 (0.014, 0.035)	0.021 (0.014, 0.033)
-+++	graduation	0	22	13	166	69
-+++	futility	0	193	234	21	106
-+++	max_n	0	0	0	0	0
-+++	n	36 (28, 47)	15 (6, 33)	14 (6, 35)	15 (5, 32)	18 (7, 37)
-+++	n_unique	36 (28, 47)	15 (6, 33)	14 (6, 35)	15 (5, 32)	18 (7, 37)
-+++	post_p	NA (NA, NA)	0.44 (0.12, 0.78)	0.4 (0.13, 0.8)	0.58 (0.2, 0.87)	0.53 (0.21, 0.86)
-+++	rate	0.023 (0.017, 0.031)	0.026 (0.017, 0.042)	0.027 (0.016, 0.042)	0.022 (0.014, 0.04)	0.023 (0.015, 0.036)
+—	graduation	0	8	6	385	47
+—	futility	0	22	30	0	11
+—	max_n	0	0	0	0	0
+—	n	41 (32, 51)	16 (7, 30)	15 (7, 31)	27 (14, 40)	18 (7, 31)
+—	n_unique	41 (32, 51)	16 (7, 30)	15 (7, 31)	27 (14, 40)	18 (7, 31)
+—	post_p	NA (NA, NA)	0.38 (0.1, 0.79)	0.38 (0.1, 0.8)	0.98 (0.81, 1)	0.5 (0.16, 0.86)
+—	rate	0.023 (0.017, 0.031)	0.025 (0.016, 0.043)	0.025 (0.015, 0.043)	0.009 (0.005, 0.015)	0.022 (0.014, 0.036)
+–+	graduation	0	11	7	391	54
+–+	futility	0	86	111	2	61
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+–+	rate	0 (0, 0)	0 (0, 0)	0 (0, 0.174)	0 (0, 0)	0 (0, 0.02)
+-+-	graduation	0	14	13	395	64
+-+-	futility	0	96	109	2	37
+-+-	max_n	0	0	0	0	0
+-+-	n	28 (21, 38)	11 (5, 22)	11 (5, 22)	18 (8, 27)	13 (5, 25)
+-+-	n_unique	28 (21, 38)	11 (5, 22)	11 (5, 22)	18 (8, 27)	13 (5, 25)
+-+-	post_p	NA (NA, NA)	0.36 (0.1, 0.74)	0.37 (0.11, 0.74)	0.94 (0.73, 1)	0.52 (0.17, 0.87)
+-+-	rate	0.023 (0.016, 0.031)	0.026 (0.015, 0.05)	0.026 (0.014, 0.049)	0.009 (0.005, 0.016)	0.021 (0.011, 0.041)
+-++	graduation	0	16	14	400	71
+-++	futility	0	141	163	4	82
+-++	max_n	0	0	0	0	0
+-++	n	6 (3, 10)	4 (1, 7)	3 (1, 6)	3 (1, 6)	4 (1, 7)
+-++	n_unique	6 (3, 10)	4 (1, 7)	3 (1, 6)	3 (1, 6)	4 (1, 7)
+-++	post_p	NA (NA, NA)	0.48 (0.28, 0.65)	0.46 (0.28, 0.65)	0.59 (0.45, 0.78)	0.48 (0.29, 0.67)
+-++	rate	0.025 (0.007, 0.048)	0.024 (0, 0.055)	0.027 (0, 0.081)	0.009 (0, 0.031)	0.022 (0, 0.056)
++–	graduation	0	15	8	392	66
++–	futility	0	120	154	8	56
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
++–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
++–	post_p	NA (NA, NA)	0.49 (0.43, 0.57)	0.49 (0.43, 0.56)	0.53 (0.45, 0.59)	0.51 (0.44, 0.57)
++–	rate	0.022 (0, 0.086)	0.022 (0, 0.092)	0.027 (0, 0.108)	0 (0, 0.049)	0.016 (0, 0.1)
++-+	graduation	0	18	9	397	72
++-+	futility	0	162	194	10	92
++-+	max_n	0	0	0	0	0
++-+	n	7 (4, 12)	4 (1, 8)	4 (1, 8)	4 (1, 9)	5 (2, 9)
++-+	n_unique	7 (4, 12)	4 (1, 8)	4 (1, 8)	4 (1, 9)	5 (2, 9)
++-+	post_p	NA (NA, NA)	0.44 (0.25, 0.67)	0.46 (0.25, 0.69)	0.64 (0.47, 0.89)	0.47 (0.26, 0.7)
++-+	rate	0.023 (0.01, 0.044)	0.027 (0.008, 0.069)	0.025 (0.006, 0.062)	0.008 (0, 0.024)	0.023 (0.008, 0.055)
+++-	graduation	0	20	15	399	78
+++-	futility	0	170	209	10	78
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+++-	rate	0 (0, 0.135)	0.086 (0.017, 0.177)	0.053 (0.049, 0.056)	0 (0, 0.041)	0 (0, 0)
++++	graduation	0	22	16	403	84
++++	futility	0	199	236	12	112
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	0.52 (0.51, 0.52)	0.51 (0.48, 0.54)	0.51 (0.48, 0.54)	0.52 (0.51, 0.52)
++++	rate	0 (0, 0.195)	0.021 (0, 0.092)	0.036 (0, 0.127)	0.007 (0, 0.084)	0.015 (0, 0.087)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	6	3	73	26
all	time_stop	10 (9, 19)	11 (11, 17)	20 (12, 49)	15 (12, 32)
all	n_trt	66 (60, 120)	72 (72, 100)	110 (60, 276)	86 (56, 217)
all	n_control	80 (71, 162)	95 (89, 135)	166 (99, 477)	122 (94, 285)
all	post_p	0.96 (0.88, 0.99)	0.94 (0.92, 0.96)	0.97 (0.91, 1)	0.96 (0.91, 0.99)
all	order	1 (1, 1.5)	1 (1, 1)	1 (1, 2.8)	1 (1, 2)
HRD+	count	2	3	321	21
HRD+	time_stop	55 (51, 59)	49 (45, 58)	45 (37, 55)	50 (41, 58)
HRD+	n_trt	52 (51, 54)	50 (50, 51)	52 (50, 64)	52 (50, 62)
HRD+	n_control	76 (74, 78)	69 (66, 84)	59 (44, 77)	67 (49, 76)
HRD+	post_p	0.94 (0.89, 0.99)	0.99 (0.94, 0.99)	1 (0.96, 1)	0.97 (0.92, 1)
HRD+	order	2 (2, 2)	2 (2, 2)	1 (1, 2)	2 (1, 3)
TP53+	count	9	3	49	26
TP53+	time_stop	26 (23, 55)	48 (45, 54)	35 (24, 53)	36 (23, 56)
TP53+	n_trt	60 (52, 143)	105 (103, 119)	75 (51, 115)	80 (55, 152)
TP53+	n_control	85 (68, 213)	183 (147, 189)	114 (73, 208)	124 (72, 198)
TP53+	post_p	0.96 (0.92, 0.98)	0.97 (0.94, 0.99)	0.97 (0.93, 1)	0.97 (0.9, 1)
TP53+	order	1 (1, 2)	2 (1.2, 2.8)	1 (1, 3)	2 (1, 3.5)
TEfus+	count	6	7	52	21
TEfus+	time_stop	28 (25, 38)	36 (33, 47)	41 (30, 54)	28 (24, 48)
TEfus+	n_trt	54 (51, 62)	92 (57, 103)	81 (55, 124)	61 (50, 109)
TEfus+	n_control	78 (61, 114)	118 (91, 135)	127 (77, 173)	81 (64, 156)
TEfus+	post_p	0.95 (0.86, 0.97)	0.94 (0.88, 0.99)	0.99 (0.94, 1)	0.99 (0.89, 1)
TEfus+	order	1 (1, 1.5)	1 (1, 2.8)	2 (1, 3)	1 (1, 3)
PI3K+	count	3	1	44	13
PI3K+	time_stop	32 (27, 38)	33 (33, 33)	39 (26, 55)	45 (27, 56)
PI3K+	n_trt	64 (56, 69)	67 (67, 67)	76 (51, 124)	104 (62, 140)
PI3K+	n_control	86 (69, 108)	112 (112, 112)	124 (72, 195)	143 (82, 195)
PI3K+	post_p	0.94 (0.89, 0.98)	0.96 (0.96, 0.96)	0.99 (0.95, 1)	0.99 (0.96, 1)
PI3K+	order	1 (1, 1)	1 (1, 1)	2 (1, 3.7)	2 (1, 4)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	15	24		1
all	time_stop	41 (22, 53)	38 (11, 56)		40 (40, 40)
all	n_trt	152 (102, 243)	138 (67, 216)		132 (132, 132)
all	n_control	426 (180, 549)	354 (90, 592)		367 (367, 367)
all	post_p	0.01 (0, 0.09)	0.03 (0, 0.16)		0.02 (0.02, 0.02)
all	order	2 (1, 4)	2.5 (1, 4.7)		3 (3, 3)
HRD+	count	8	6		10
HRD+	time_stop	56 (53, 59)	58 (52, 60)		57 (52, 60)
HRD+	n_trt	55 (52, 57)	50 (50, 64)		54 (50, 60)
HRD+	n_control	87 (73, 96)	80 (72, 86)		80 (69, 100)
HRD+	post_p	0.17 (0.01, 0.29)	0.2 (0.07, 0.28)		0.2 (0.12, 0.27)
HRD+	order	2.5 (1, 5)	2.5 (1.5, 4.5)		2.5 (1.9, 4)
TP53+	count	106	140	17	47
TP53+	time_stop	42 (30, 54)	34 (21, 52)	41 (29, 56)	35 (27, 56)
TP53+	n_trt	66 (50, 98)	62 (51, 98)	54 (51, 115)	59 (50, 94)
TP53+	n_control	153 (88, 202)	115 (62, 190)	135 (95, 217)	117 (81, 212)
TP53+	post_p	0.1 (0.01, 0.23)	0.11 (0.02, 0.25)	0.13 (0.04, 0.23)	0.12 (0.03, 0.24)
TP53+	order	2 (1, 3)	1 (1, 3)	1 (1, 2.4)	2 (1, 3)
TEfus+	count	83	93	2	29
TEfus+	time_stop	42 (32, 57)	40 (29, 56)	38 (34, 41)	39 (30, 57)
TEfus+	n_trt	66 (52, 95)	61 (51, 92)	66 (53, 78)	63 (50, 92)
TEfus+	n_control	130 (87, 186)	118 (73, 187)	112 (104, 119)	114 (82, 190)
TEfus+	post_p	0.1 (0.02, 0.21)	0.1 (0.02, 0.19)	0.12 (0.11, 0.13)	0.14 (0.03, 0.26)
TEfus+	order	2 (1, 3)	2 (1, 3.8)	1 (1, 1)	1 (1, 3.2)
PI3K+	count	73	97	2	54
PI3K+	time_stop	44 (30, 57)	39 (28, 57)	46 (44, 48)	32 (23, 48)
PI3K+	n_trt	65 (50, 98)	62 (51, 95)	70 (65, 74)	57 (50, 90)
PI3K+	n_control	144 (87, 198)	128 (76, 203)	160 (149, 172)	100 (62, 154)
PI3K+	post_p	0.09 (0.03, 0.21)	0.1 (0.02, 0.2)	0.09 (0.08, 0.09)	0.13 (0.04, 0.25)
PI3K+	order	2 (1, 3)	2 (1, 4)	2.5 (1.3, 3.7)	1.5 (1, 3)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
all	TC1	time	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)	10 (9, 19)
all	TC1	n	28 (23, 39)	6 (4, 16)	1 (0, 2)	7 (3, 14)	9 (6, 15)	6 (5, 11)	4 (3, 12)	4 (0, 6)	4 (1, 6)	0 (0, 0)	2 (0, 4)	0 (0, 0)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.64 (0.6, 0.78)	0.55 (0.52, 0.76)	0.51 (0.51, 0.52)	0.58 (0.52, 0.61)	0.56 (0.53, 0.57)	0.53 (0.51, 0.6)	0.57 (0.54, 0.61)	0.53 (0.5, 0.53)	0.53 (0.5, 0.58)	NA (NA, NA)	0.53 (0.51, 0.56)	0.56 (0.56, 0.56)	NA (NA, NA)	0.52 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.009 (0, 0.015)	0 (0, 0.002)	0 (0, 0)	0 (0, 0.027)	0 (0, 0.011)	0 (0, 0.017)	0 (0, 0.011)	0 (0, 0.007)	0 (0, 0.007)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC2	time	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)	11 (11, 17)
all	TC2	n	26 (24, 28)	2 (2, 10)	1 (0, 3)	8 (6, 9)	16 (15, 21)	8 (8, 11)	8 (4, 9)	5 (2, 5)	3 (3, 5)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 1)	1 (0, 2)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.52 (0.51, 0.61)	0.53 (0.52, 0.57)	0.53 (0.52, 0.54)	0.56 (0.56, 0.68)	0.56 (0.55, 0.61)	0.5 (0.5, 0.65)	0.57 (0.54, 0.57)	0.54 (0.53, 0.56)	0.53 (0.51, 0.53)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)	NA (NA, NA)	0.51 (0.51, 0.52)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.013 (0.008, 0.019)	0 (0, 0.016)	0.014 (0.003, 0.024)	0 (0, 0.019)	0.005 (0.001, 0.008)	0.021 (0.004, 0.024)	0 (0, 0.008)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	73	73	73	73	73	73	73	73	73	73	73	73	73	73	73	73
all	TC3	time	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)	20 (12, 49)
all	TC3	n	31 (14, 92)	7 (3, 23)	2 (0, 7)	10 (4, 27)	14 (6, 32)	8 (3, 23)	8 (3, 19)	7 (2, 18)	12 (7, 25)	0 (0, 0)	9 (4, 16)	1 (0, 5)	0 (0, 1)	2 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.65 (0.54, 0.89)	0.56 (0.51, 0.82)	0.55 (0.51, 0.78)	0.56 (0.52, 0.78)	0.58 (0.51, 0.82)	0.58 (0.52, 0.8)	0.56 (0.51, 0.72)	0.56 (0.52, 0.78)	0.59 (0.52, 0.99)	NA (NA, NA)	0.57 (0.51, 0.85)	0.54 (0.51, 0.62)	0.56 (0.52, 0.57)	0.53 (0.5, 0.62)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.013 (0, 0.021)	0 (0, 0.02)	0 (0, 0.017)	0.011 (0, 0.023)	0.009 (0, 0.024)	0.007 (0, 0.022)	0 (0, 0.021)	0.01 (0, 0.022)	0.004 (0, 0.013)	NA (NA, NA)	0 (0, 0.017)	0 (0, 0.017)	0 (0, 0.014)	0 (0, 0.011)	NA (NA, NA)	0 (0, 0)
all	TC4	count	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26	26
all	TC4	time	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)	15 (12, 32)
all	TC4	n	25 (14, 70)	7 (3, 16)	1 (0, 4)	12 (5, 26)	9 (4, 28)	10 (4, 23)	5 (2, 10)	7 (4, 13)	4 (2, 16)	0 (0, 0)	3 (0, 7)	2 (0, 3)	0 (0, 1)	1 (0, 4)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.7 (0.54, 0.85)	0.56 (0.52, 0.64)	0.52 (0.51, 0.59)	0.56 (0.52, 0.82)	0.57 (0.53, 0.76)	0.57 (0.51, 0.81)	0.54 (0.51, 0.64)	0.55 (0.51, 0.65)	0.55 (0.51, 0.73)	NA (NA, NA)	0.52 (0.5, 0.55)	0.54 (0.52, 0.59)	0.5 (0.5, 0.5)	0.53 (0.5, 0.57)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.01 (0, 0.019)	0 (0, 0.02)	0 (0, 0.012)	0.008 (0, 0.018)	0 (0, 0.017)	0 (0, 0.018)	0 (0, 0.027)	0 (0, 0.023)	0 (0, 0.016)	0 (0, 0)	0 (0, 0.017)	0 (0, 0.013)	0 (0, 0.014)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									2	2	2	2	2	2	2	2
HRD+	TC1	time									55 (51, 59)	55 (51, 59)	55 (51, 59)	55 (51, 59)	55 (51, 59)	55 (51, 59)	55 (51, 59)	55 (51, 59)
HRD+	TC1	n									30 (30, 30)	0 (0, 0)	16 (15, 16)	2 (1, 3)	0 (0, 0)	5 (4, 6)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.8 (0.73, 0.88)	NA (NA, NA)	0.83 (0.74, 0.92)	0.57 (0.55, 0.6)	NA (NA, NA)	0.58 (0.52, 0.65)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.013 (0.009, 0.017)	NA (NA, NA)	0.01 (0.005, 0.015)	0.007 (0.001, 0.013)	NA (NA, NA)	0.026 (0.018, 0.035)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									3	3	3	3	3	3	3	3
HRD+	TC2	time									49 (45, 58)	49 (45, 58)	49 (45, 58)	49 (45, 58)	49 (45, 58)	49 (45, 58)	49 (45, 58)	49 (45, 58)
HRD+	TC2	n									28 (26, 30)	0 (0, 0)	12 (10, 17)	2 (0, 4)	0 (0, 2)	6 (4, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.91 (0.85, 0.98)	NA (NA, NA)	0.8 (0.69, 0.91)	0.59 (0.58, 0.59)	NA (NA, NA)	0.59 (0.56, 0.65)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.014 (0.011, 0.015)	NA (NA, NA)	0.01 (0.01, 0.021)	0.005 (0.001, 0.009)	0.107 (0.107, 0.107)	0.011 (0.009, 0.015)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									321	321	321	321	321	321	321	321
HRD+	TC3	time									45 (37, 55)	45 (37, 55)	45 (37, 55)	45 (37, 55)	45 (37, 55)	45 (37, 55)	45 (37, 55)	45 (37, 55)
HRD+	TC3	n									27 (20, 36)	0 (0, 0)	18 (10, 25)	3 (1, 6)	1 (0, 2)	5 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.94 (0.78, 1)	NA (NA, NA)	0.87 (0.71, 0.99)	0.56 (0.51, 0.71)	0.54 (0.5, 0.58)	0.59 (0.52, 0.78)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.008 (0.004, 0.014)	0 (0, 0)	0.007 (0.003, 0.014)	0 (0, 0.023)	0 (0, 0.035)	0.006 (0, 0.019)	0.019 (0.004, 0.034)	0.01 (0, 0.169)
HRD+	TC4	count									21	21	21	21	21	21	21	21
HRD+	TC4	time									50 (41, 58)	50 (41, 58)	50 (41, 58)	50 (41, 58)	50 (41, 58)	50 (41, 58)	50 (41, 58)	50 (41, 58)
HRD+	TC4	n									26 (18, 30)	0 (0, 0)	17 (10, 25)	5 (1, 7)	1 (0, 2)	6 (3, 9)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.82 (0.73, 0.94)	NA (NA, NA)	0.82 (0.71, 0.94)	0.56 (0.51, 0.64)	0.53 (0.52, 0.56)	0.59 (0.53, 0.77)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.012 (0.007, 0.02)	NA (NA, NA)	0.011 (0.004, 0.019)	0.011 (0, 0.022)	0 (0, 0.018)	0.014 (0.008, 0.028)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					9	9	9	9					9	9	9	9
TP53+	TC1	time					26 (23, 55)	26 (23, 55)	26 (23, 55)	26 (23, 55)					26 (23, 55)	26 (23, 55)	26 (23, 55)	26 (23, 55)
TP53+	TC1	n					27 (20, 39)	16 (10, 38)	22 (6, 33)	10 (3, 34)					0 (0, 0)	3 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.75 (0.72, 0.83)	0.72 (0.53, 0.89)	0.76 (0.53, 0.94)	0.71 (0.55, 0.83)					0.63 (0.63, 0.63)	0.53 (0.52, 0.68)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.016 (0.007, 0.022)	0.013 (0.006, 0.019)	0.011 (0, 0.023)	0 (0, 0.015)					0 (0, 0)	0.013 (0, 0.024)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					3	3	3	3					3	3	3	3
TP53+	TC2	time					48 (45, 54)	48 (45, 54)	48 (45, 54)	48 (45, 54)					48 (45, 54)	48 (45, 54)	48 (45, 54)	48 (45, 54)
TP53+	TC2	n					35 (30, 42)	33 (27, 34)	22 (12, 33)	15 (11, 21)					0 (0, 0)	5 (3, 7)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.86 (0.74, 0.95)	0.71 (0.71, 0.79)	0.71 (0.58, 0.77)	0.81 (0.66, 0.95)					NA (NA, NA)	0.51 (0.51, 0.56)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.02 (0.016, 0.02)	0.018 (0.013, 0.019)	0.018 (0.017, 0.026)	0.015 (0.011, 0.019)					NA (NA, NA)	0.014 (0.012, 0.018)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					49	49	49	49					49	49	49	49
TP53+	TC3	time					35 (24, 53)	35 (24, 53)	35 (24, 53)	35 (24, 53)					35 (24, 53)	35 (24, 53)	35 (24, 53)	35 (24, 53)
TP53+	TC3	n					24 (16, 50)	19 (8, 35)	12 (6, 34)	10 (6, 20)					0 (0, 2)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.76 (0.71, 0.92)	0.75 (0.56, 0.89)	0.73 (0.52, 0.95)	0.73 (0.53, 0.87)					0.54 (0.51, 0.57)	0.55 (0.51, 0.69)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.013 (0.005, 0.019)	0.013 (0, 0.02)	0.014 (0, 0.023)	0.015 (0, 0.023)					0 (0, 0.028)	0 (0, 0.014)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					26	26	26	26					26	26	26	26
TP53+	TC4	time					36 (23, 56)	36 (23, 56)	36 (23, 56)	36 (23, 56)					36 (23, 56)	36 (23, 56)	36 (23, 56)	36 (23, 56)
TP53+	TC4	n					31 (21, 61)	20 (13, 42)	10 (6, 36)	10 (6, 27)					0 (0, 2)	4 (2, 8)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.8 (0.74, 0.91)	0.77 (0.72, 0.9)	0.72 (0.52, 0.86)	0.68 (0.55, 0.82)					0.52 (0.51, 0.55)	0.56 (0.51, 0.72)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.012 (0.009, 0.018)	0.013 (0.004, 0.019)	0.013 (0, 0.022)	0.015 (0, 0.022)					0 (0, 0.028)	0 (0, 0.021)	NA (NA, NA)	0 (0, 0)
TEfus+	TC1	count			6	6			6	6			6	6			6	6
TEfus+	TC1	time			28 (25, 38)	28 (25, 38)			28 (25, 38)	28 (25, 38)			28 (25, 38)	28 (25, 38)			28 (25, 38)	28 (25, 38)
TEfus+	TC1	n			3 (2, 4)	22 (11, 24)			12 (8, 19)	10 (7, 16)			8 (4, 10)	2 (1, 3)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.53 (0.51, 0.61)	0.75 (0.62, 0.84)			0.73 (0.55, 0.9)	0.63 (0.52, 0.73)			0.56 (0.52, 0.66)	0.55 (0.5, 0.59)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.009 (0, 0.034)	0.016 (0.006, 0.025)			0.007 (0.006, 0.016)	0.018 (0.003, 0.022)			0.01 (0, 0.014)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	count			7	7			7	7			7	7			7	7
TEfus+	TC2	time			36 (33, 47)	36 (33, 47)			36 (33, 47)	36 (33, 47)			36 (33, 47)	36 (33, 47)			36 (33, 47)	36 (33, 47)
TEfus+	TC2	n			5 (5, 6)	30 (13, 34)			23 (16, 35)	21 (9, 27)			9 (8, 10)	1 (0, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.55 (0.51, 0.63)	0.76 (0.74, 0.96)			0.78 (0.74, 0.86)	0.72 (0.53, 0.81)			0.57 (0.52, 0.63)	0.58 (0.57, 0.64)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.019 (0.011, 0.029)	0.016 (0.01, 0.019)			0.014 (0.007, 0.02)	0.015 (0.011, 0.026)			0.012 (0.005, 0.018)	0 (0, 0.009)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			52	52			52	52			52	52			52	52
TEfus+	TC3	time			41 (30, 54)	41 (30, 54)			41 (30, 54)	41 (30, 54)			41 (30, 54)	41 (30, 54)			41 (30, 54)	41 (30, 54)
TEfus+	TC3	n			4 (1, 8)	25 (17, 45)			18 (8, 38)	14 (8, 22)			15 (8, 22)	2 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.6 (0.51, 0.75)	0.8 (0.71, 0.92)			0.75 (0.54, 0.95)	0.72 (0.57, 0.86)			0.79 (0.6, 0.97)	0.56 (0.52, 0.66)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.009 (0, 0.026)	0.014 (0.007, 0.02)			0.014 (0.008, 0.021)	0.013 (0, 0.02)			0.007 (0, 0.016)	0 (0, 0.026)			NA (NA, NA)	0 (0, 0)
TEfus+	TC4	count			21	21			21	21			21	21			21	21
TEfus+	TC4	time			28 (24, 48)	28 (24, 48)			28 (24, 48)	28 (24, 48)			28 (24, 48)	28 (24, 48)			28 (24, 48)	28 (24, 48)
TEfus+	TC4	n			4 (1, 8)	26 (21, 37)			12 (5, 29)	11 (7, 18)			7 (5, 15)	2 (1, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.55 (0.51, 0.73)	0.83 (0.7, 0.97)			0.74 (0.51, 0.84)	0.71 (0.56, 0.83)			0.59 (0.51, 0.87)	0.53 (0.51, 0.56)			NA (NA, NA)	0.53 (0.53, 0.53)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0.021)	0.012 (0.006, 0.016)			0.011 (0, 0.02)	0.012 (0.005, 0.016)			0.008 (0, 0.018)	0 (0, 0.024)			NA (NA, NA)	0 (0, 0)
PI3K+	TC1	count		3		3		3		3		3		3		3		3
PI3K+	TC1	time		32 (27, 38)		32 (27, 38)		32 (27, 38)		32 (27, 38)		32 (27, 38)		32 (27, 38)		32 (27, 38)		32 (27, 38)
PI3K+	TC1	n		14 (11, 18)		23 (22, 25)		13 (7, 19)		12 (8, 13)		0 (0, 0)		1 (1, 2)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	post_p		0.7 (0.65, 0.74)		0.74 (0.73, 0.77)		0.82 (0.67, 0.84)		0.75 (0.61, 0.76)		NA (NA, NA)		0.54 (0.53, 0.55)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.013 (0.01, 0.014)		0.018 (0.01, 0.018)		0.012 (0.012, 0.013)		0.012 (0.002, 0.015)		NA (NA, NA)		0 (0, 0)		NA (NA, NA)		NA (NA, NA)
PI3K+	TC2	count		1		1		1		1		1		1		1		1
PI3K+	TC2	time		33 (33, 33)		33 (33, 33)		33 (33, 33)		33 (33, 33)		33 (33, 33)		33 (33, 33)		33 (33, 33)		33 (33, 33)
PI3K+	TC2	n		6 (6, 6)		29 (29, 29)		17 (17, 17)		8 (8, 8)		0 (0, 0)		2 (2, 2)		5 (5, 5)		0 (0, 0)
PI3K+	TC2	post_p		0.63 (0.63, 0.63)		0.86 (0.86, 0.86)		0.76 (0.76, 0.76)		0.6 (0.6, 0.6)		NA (NA, NA)		0.52 (0.52, 0.52)		0.51 (0.51, 0.51)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.013 (0.013, 0.013)		0.009 (0.009, 0.009)		0.012 (0.012, 0.012)		0.022 (0.022, 0.022)		NA (NA, NA)		0.194 (0.194, 0.194)		0.016 (0.016, 0.016)		NA (NA, NA)
PI3K+	TC3	count		44		44		44		44		44		44		44		44
PI3K+	TC3	time		39 (26, 55)		39 (26, 55)		39 (26, 55)		39 (26, 55)		39 (26, 55)		39 (26, 55)		39 (26, 55)		39 (26, 55)
PI3K+	TC3	n		17 (7, 34)		23 (15, 36)		18 (10, 32)		13 (6, 21)		0 (0, 0)		2 (0, 6)		4 (1, 6)		0 (0, 0)
PI3K+	TC3	post_p		0.75 (0.54, 0.92)		0.8 (0.71, 0.92)		0.79 (0.62, 0.93)		0.73 (0.52, 0.92)		NA (NA, NA)		0.54 (0.5, 0.7)		0.57 (0.51, 0.69)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.012 (0.002, 0.018)		0.012 (0.002, 0.019)		0.014 (0.001, 0.019)		0.013 (0, 0.022)		0 (0, 0)		0 (0, 0.026)		0 (0, 0.021)		NA (NA, NA)
PI3K+	TC4	count		13		13		13		13		13		13		13		13
PI3K+	TC4	time		45 (27, 56)		45 (27, 56)		45 (27, 56)		45 (27, 56)		45 (27, 56)		45 (27, 56)		45 (27, 56)		45 (27, 56)
PI3K+	TC4	n		17 (8, 25)		28 (23, 51)		27 (16, 33)		15 (7, 23)		0 (0, 0)		3 (1, 7)		4 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.73 (0.65, 0.84)		0.87 (0.73, 0.99)		0.82 (0.71, 0.9)		0.76 (0.62, 0.89)		NA (NA, NA)		0.54 (0.52, 0.61)		0.55 (0.52, 0.66)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.015 (0.013, 0.017)		0.013 (0.008, 0.022)		0.014 (0.006, 0.021)		0.013 (0.009, 0.02)		NA (NA, NA)		0 (0, 0.023)		0.011 (0, 0.017)		NA (NA, NA)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15
all	TC1	time	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)	41 (22, 53)
all	TC1	n	35 (24, 94)	11 (6, 19)	4 (2, 8)	15 (8, 30)	15 (9, 37)	8 (5, 24)	11 (8, 23)	8 (4, 15)	8 (5, 16)	0 (0, 0)	6 (4, 11)	1 (0, 4)	0 (0, 1)	3 (0, 4)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.15 (0.05, 0.44)	0.36 (0.22, 0.46)	0.41 (0.22, 0.49)	0.29 (0.09, 0.45)	0.28 (0.1, 0.48)	0.35 (0.1, 0.47)	0.36 (0.18, 0.47)	0.3 (0.18, 0.41)	0.4 (0.15, 0.49)	NA (NA, NA)	0.33 (0.12, 0.48)	0.45 (0.41, 0.49)	0.48 (0.42, 0.49)	0.44 (0.34, 0.47)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.029 (0.022, 0.034)	0.03 (0.024, 0.042)	0.033 (0.018, 0.105)	0.027 (0.019, 0.041)	0.027 (0.021, 0.046)	0.028 (0.022, 0.067)	0.026 (0.016, 0.032)	0.036 (0.026, 0.07)	0.025 (0.018, 0.093)	NA (NA, NA)	0.032 (0.022, 0.078)	0.031 (0, 0.463)	0.022 (0, 0.064)	0.051 (0.019, 0.205)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	24	24	24	24	24	24	24	24	24	24	24	24	24	24	24	24
all	TC2	time	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)	38 (11, 56)
all	TC2	n	30 (17, 91)	10 (2, 18)	4 (1, 9)	15 (7, 21)	14 (10, 26)	9 (5, 21)	10 (5, 22)	9 (4, 15)	6 (2, 17)	0 (0, 0)	5 (2, 12)	2 (0, 5)	0 (0, 1)	1 (0, 4)	0 (0, 0)	0 (0, 1)
all	TC2	post_p	0.29 (0.12, 0.45)	0.34 (0.17, 0.49)	0.43 (0.22, 0.48)	0.37 (0.15, 0.45)	0.34 (0.09, 0.46)	0.29 (0.13, 0.47)	0.31 (0.15, 0.45)	0.37 (0.22, 0.48)	0.38 (0.19, 0.45)	NA (NA, NA)	0.42 (0.16, 0.49)	0.46 (0.38, 0.49)	0.43 (0.43, 0.43)	0.45 (0.3, 0.5)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.027 (0.022, 0.033)	0.033 (0.014, 0.049)	0.027 (0, 0.051)	0.03 (0.021, 0.037)	0.03 (0.016, 0.037)	0.028 (0.018, 0.054)	0.031 (0.023, 0.047)	0.026 (0.017, 0.042)	0.029 (0.016, 0.069)	NA (NA, NA)	0.028 (0, 0.078)	0.029 (0, 0.08)	0.019 (0, 0.04)	0.034 (0, 0.104)	NA (NA, NA)	0 (0, 0)
all	TC4	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
all	TC4	time	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)	40 (40, 40)
all	TC4	n	12 (12, 12)	7 (7, 7)	7 (7, 7)	25 (25, 25)	9 (9, 9)	18 (18, 18)	19 (19, 19)	4 (4, 4)	16 (16, 16)	0 (0, 0)	10 (10, 10)	3 (3, 3)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.09 (0.09, 0.09)	0.31 (0.31, 0.31)	0.11 (0.11, 0.11)	0.41 (0.41, 0.41)	0.23 (0.23, 0.23)	0.49 (0.49, 0.49)	0.41 (0.41, 0.41)	0.06 (0.06, 0.06)	0.48 (0.48, 0.48)	NA (NA, NA)	0.43 (0.43, 0.43)	0.5 (0.5, 0.5)	NA (NA, NA)	0.26 (0.26, 0.26)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.047 (0.047, 0.047)	0.037 (0.037, 0.037)	0.048 (0.048, 0.048)	0.024 (0.024, 0.024)	0.032 (0.032, 0.032)	0.021 (0.021, 0.021)	0.025 (0.025, 0.025)	0.081 (0.081, 0.081)	0.016 (0.016, 0.016)	NA (NA, NA)	0.016 (0.016, 0.016)	0.02 (0.02, 0.02)	NA (NA, NA)	0.091 (0.091, 0.091)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									8	8	8	8	8	8	8	8
HRD+	TC1	time									56 (53, 59)	56 (53, 59)	56 (53, 59)	56 (53, 59)	56 (53, 59)	56 (53, 59)	56 (53, 59)	56 (53, 59)
HRD+	TC1	n									26 (11, 34)	0 (0, 0)	18 (12, 28)	5 (2, 8)	0 (0, 1)	4 (3, 7)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.28 (0.12, 0.42)	NA (NA, NA)	0.28 (0.15, 0.48)	0.42 (0.37, 0.48)	0.45 (0.45, 0.45)	0.42 (0.39, 0.46)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.026 (0.019, 0.033)	NA (NA, NA)	0.027 (0.022, 0.038)	0.037 (0.027, 0.052)	0.018 (0.004, 0.049)	0.025 (0.019, 0.037)	NA (NA, NA)	0 (0, 0)
HRD+	TC2	count									6	6	6	6	6	6	6	6
HRD+	TC2	time									58 (52, 60)	58 (52, 60)	58 (52, 60)	58 (52, 60)	58 (52, 60)	58 (52, 60)	58 (52, 60)	58 (52, 60)
HRD+	TC2	n									27 (18, 31)	0 (0, 0)	20 (12, 27)	4 (2, 6)	0 (0, 0)	4 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.26 (0.18, 0.38)	NA (NA, NA)	0.32 (0.3, 0.37)	0.43 (0.33, 0.45)	NA (NA, NA)	0.45 (0.38, 0.48)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.022 (0.019, 0.034)	NA (NA, NA)	0.023 (0.02, 0.035)	0.026 (0.022, 0.042)	0.141 (0.141, 0.141)	0.023 (0.016, 0.038)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									10	10	10	10	10	10	10	10
HRD+	TC4	time									57 (52, 60)	57 (52, 60)	57 (52, 60)	57 (52, 60)	57 (52, 60)	57 (52, 60)	57 (52, 60)	57 (52, 60)
HRD+	TC4	n									26 (20, 36)	0 (0, 0)	14 (7, 24)	4 (3, 7)	0 (0, 3)	6 (4, 6)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.44 (0.4, 0.49)	NA (NA, NA)	0.22 (0.18, 0.4)	0.43 (0.32, 0.48)	0.45 (0.45, 0.45)	0.39 (0.19, 0.45)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.02 (0.018, 0.027)	0 (0, 0)	0.03 (0.019, 0.037)	0.026 (0.02, 0.038)	0.037 (0.02, 0.053)	0.032 (0.023, 0.064)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					106	106	106	106					106	106	106	106
TP53+	TC1	time					42 (30, 54)	42 (30, 54)	42 (30, 54)	42 (30, 54)					42 (30, 54)	42 (30, 54)	42 (30, 54)	42 (30, 54)
TP53+	TC1	n					21 (11, 39)	14 (8, 24)	12 (7, 26)	11 (5, 25)					0 (0, 2)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.33 (0.07, 0.48)	0.32 (0.13, 0.47)	0.3 (0.12, 0.46)	0.38 (0.16, 0.48)					0.46 (0.41, 0.49)	0.44 (0.33, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.025 (0.019, 0.04)	0.027 (0.021, 0.045)	0.03 (0.02, 0.05)	0.028 (0.021, 0.045)					0.026 (0, 0.091)	0.035 (0.011, 0.083)	0 (0, 0)	0 (0, 0.026)
TP53+	TC2	count					140	140	140	140					140	140	140	140
TP53+	TC2	time					34 (21, 52)	34 (21, 52)	34 (21, 52)	34 (21, 52)					34 (21, 52)	34 (21, 52)	34 (21, 52)	34 (21, 52)
TP53+	TC2	n					20 (12, 37)	14 (7, 30)	14 (9, 24)	10 (6, 20)					0 (0, 1)	2 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.33 (0.08, 0.48)	0.32 (0.12, 0.48)	0.38 (0.11, 0.48)	0.37 (0.17, 0.48)					0.47 (0.42, 0.5)	0.45 (0.32, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.026 (0.018, 0.037)	0.026 (0.018, 0.045)	0.027 (0.016, 0.04)	0.027 (0.018, 0.043)					0 (0, 0.089)	0.032 (0, 0.096)	NA (NA, NA)	0.023 (0, 0.202)
TP53+	TC3	count					17	17	17	17					17	17	17	17
TP53+	TC3	time					41 (29, 56)	41 (29, 56)	41 (29, 56)	41 (29, 56)					41 (29, 56)	41 (29, 56)	41 (29, 56)	41 (29, 56)
TP53+	TC3	n					19 (11, 49)	17 (8, 35)	12 (10, 20)	8 (5, 12)					0 (0, 2)	3 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.32 (0.16, 0.44)	0.39 (0.19, 0.48)	0.34 (0.2, 0.47)	0.34 (0.16, 0.46)					0.48 (0.48, 0.48)	0.48 (0.44, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.027 (0.021, 0.036)	0.026 (0.02, 0.034)	0.027 (0.02, 0.036)	0.032 (0.027, 0.078)					0 (0, 0.04)	0.018 (0, 0.042)	0 (0, 0)	NA (NA, NA)
TP53+	TC4	count					47	47	47	47					47	47	47	47
TP53+	TC4	time					35 (27, 56)	35 (27, 56)	35 (27, 56)	35 (27, 56)					35 (27, 56)	35 (27, 56)	35 (27, 56)	35 (27, 56)
TP53+	TC4	n					20 (10, 38)	14 (9, 18)	12 (5, 27)	11 (6, 18)					0 (0, 1)	4 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.36 (0.17, 0.47)	0.34 (0.14, 0.47)	0.42 (0.21, 0.48)	0.35 (0.17, 0.47)					0.47 (0.42, 0.49)	0.45 (0.34, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.027 (0.018, 0.044)	0.026 (0.019, 0.043)	0.025 (0.02, 0.05)	0.027 (0.018, 0.044)					0 (0, 0.072)	0.031 (0.014, 0.1)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			83	83			83	83			83	83			83	83
TEfus+	TC1	time			42 (32, 57)	42 (32, 57)			42 (32, 57)	42 (32, 57)			42 (32, 57)	42 (32, 57)			42 (32, 57)	42 (32, 57)
TEfus+	TC1	n			5 (2, 8)	20 (10, 39)			14 (8, 29)	11 (5, 21)			8 (5, 17)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.41 (0.21, 0.49)	0.35 (0.12, 0.48)			0.34 (0.13, 0.48)	0.32 (0.14, 0.45)			0.36 (0.19, 0.48)	0.45 (0.33, 0.5)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.036 (0.016, 0.099)	0.025 (0.019, 0.038)			0.028 (0.021, 0.041)	0.03 (0.022, 0.047)			0.028 (0.02, 0.049)	0.032 (0.012, 0.071)			NA (NA, NA)	0.039 (0.039, 0.039)
TEfus+	TC2	count			93	93			93	93			93	93			93	93
TEfus+	TC2	time			40 (29, 56)	40 (29, 56)			40 (29, 56)	40 (29, 56)			40 (29, 56)	40 (29, 56)			40 (29, 56)	40 (29, 56)
TEfus+	TC2	n			5 (3, 9)	18 (10, 35)			15 (9, 28)	11 (6, 19)			9 (4, 14)	2 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.42 (0.26, 0.49)	0.28 (0.11, 0.47)			0.26 (0.11, 0.46)	0.34 (0.14, 0.47)			0.38 (0.18, 0.48)	0.45 (0.36, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.029 (0.018, 0.064)	0.027 (0.019, 0.043)			0.027 (0.019, 0.041)	0.03 (0.02, 0.044)			0.029 (0.019, 0.061)	0.036 (0, 0.086)			NA (NA, NA)	0 (0, 0.137)
TEfus+	TC3	count			2	2			2	2			2	2			2	2
TEfus+	TC3	time			38 (34, 41)	38 (34, 41)			38 (34, 41)	38 (34, 41)			38 (34, 41)	38 (34, 41)			38 (34, 41)	38 (34, 41)
TEfus+	TC3	n			4 (3, 6)	18 (16, 19)			14 (11, 18)	16 (7, 24)			11 (10, 12)	2 (2, 3)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.44 (0.41, 0.46)	0.3 (0.25, 0.36)			0.28 (0.2, 0.36)	0.44 (0.39, 0.48)			0.42 (0.38, 0.46)	0.44 (0.44, 0.44)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.027 (0.025, 0.03)	0.025 (0.025, 0.025)			0.027 (0.024, 0.031)	0.03 (0.027, 0.033)			0.017 (0.015, 0.02)	0.013 (0.003, 0.023)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			29	29			29	29			29	29			29	29
TEfus+	TC4	time			39 (30, 57)	39 (30, 57)			39 (30, 57)	39 (30, 57)			39 (30, 57)	39 (30, 57)			39 (30, 57)	39 (30, 57)
TEfus+	TC4	n			4 (1, 8)	21 (13, 36)			14 (8, 21)	12 (6, 19)			9 (4, 15)	3 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.43 (0.21, 0.48)	0.36 (0.21, 0.47)			0.37 (0.17, 0.45)	0.39 (0.23, 0.47)			0.37 (0.15, 0.48)	0.45 (0.32, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.032 (0.022, 0.112)	0.023 (0.021, 0.034)			0.027 (0.021, 0.036)	0.026 (0.019, 0.042)			0.027 (0.015, 0.039)	0.034 (0.007, 0.09)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		73		73		73		73		73		73		73		73
PI3K+	TC1	time		44 (30, 57)		44 (30, 57)		44 (30, 57)		44 (30, 57)		44 (30, 57)		44 (30, 57)		44 (30, 57)		44 (30, 57)
PI3K+	TC1	n		13 (7, 22)		19 (9, 36)		15 (8, 25)		10 (6, 22)		0 (0, 0)		3 (1, 6)		3 (1, 6)		0 (0, 0)
PI3K+	TC1	post_p		0.33 (0.11, 0.46)		0.35 (0.14, 0.47)		0.32 (0.1, 0.47)		0.32 (0.13, 0.46)		NA (NA, NA)		0.45 (0.33, 0.49)		0.45 (0.29, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.029 (0.021, 0.043)		0.026 (0.021, 0.04)		0.026 (0.02, 0.043)		0.03 (0.02, 0.052)		NA (NA, NA)		0.033 (0.011, 0.083)		0.033 (0.015, 0.075)		NA (NA, NA)
PI3K+	TC2	count		97		97		97		97		97		97		97		97
PI3K+	TC2	time		39 (28, 57)		39 (28, 57)		39 (28, 57)		39 (28, 57)		39 (28, 57)		39 (28, 57)		39 (28, 57)		39 (28, 57)
PI3K+	TC2	n		14 (7, 28)		18 (10, 29)		14 (9, 29)		11 (6, 20)		0 (0, 0)		2 (0, 5)		3 (1, 6)		0 (0, 0)
PI3K+	TC2	post_p		0.35 (0.12, 0.47)		0.32 (0.11, 0.48)		0.32 (0.11, 0.47)		0.34 (0.13, 0.47)		NA (NA, NA)		0.45 (0.36, 0.49)		0.45 (0.29, 0.5)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.028 (0.02, 0.047)		0.028 (0.02, 0.04)		0.027 (0.02, 0.043)		0.028 (0.021, 0.045)		0.299 (0.299, 0.299)		0.034 (0, 0.088)		0.029 (0, 0.088)		0 (0, 0.037)
PI3K+	TC3	count		2		2		2		2		2		2		2		2
PI3K+	TC3	time		46 (44, 48)		46 (44, 48)		46 (44, 48)		46 (44, 48)		46 (44, 48)		46 (44, 48)		46 (44, 48)		46 (44, 48)
PI3K+	TC3	n		16 (14, 18)		17 (11, 23)		19 (17, 21)		15 (10, 20)		0 (0, 0)		1 (0, 2)		2 (1, 2)		0 (0, 0)
PI3K+	TC3	post_p		0.35 (0.33, 0.37)		0.22 (0.13, 0.31)		0.34 (0.3, 0.37)		0.35 (0.24, 0.47)		NA (NA, NA)		0.48 (0.48, 0.48)		0.43 (0.41, 0.45)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.023 (0.02, 0.026)		0.033 (0.029, 0.037)		0.025 (0.022, 0.029)		0.027 (0.026, 0.028)		NA (NA, NA)		0.031 (0.031, 0.031)		0.049 (0.038, 0.061)		NA (NA, NA)
PI3K+	TC4	count		54		54		54		54		54		54		54		54
PI3K+	TC4	time		32 (23, 48)		32 (23, 48)		32 (23, 48)		32 (23, 48)		32 (23, 48)		32 (23, 48)		32 (23, 48)		32 (23, 48)
PI3K+	TC4	n		11 (6, 18)		17 (11, 27)		14 (9, 24)		10 (6, 16)		0 (0, 0)		2 (0, 5)		3 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.38 (0.19, 0.48)		0.37 (0.14, 0.49)		0.35 (0.16, 0.46)		0.38 (0.2, 0.48)		NA (NA, NA)		0.44 (0.35, 0.49)		0.43 (0.31, 0.49)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.027 (0.016, 0.048)		0.025 (0.019, 0.04)		0.026 (0.019, 0.038)		0.026 (0.018, 0.046)		NA (NA, NA)		0.031 (0, 0.135)		0.028 (0, 0.089)		NA (NA, NA)