Setting description

TC3 more effective in the HRD+ biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.022, shape = 1.3 scale = 0.024, shape = 1.3
all summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 41.8, median = 34.2 mean = 39, median = 31.9
all effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.07, hr = 0.91 af = 1, hr = 1
HRD+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
HRD+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.023, shape = 1.3 scale = 0.024, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39.9, median = 32.6 mean = 39, median = 31.9
TP53+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.02, hr = 0.97 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.022, shape = 1.3 scale = 0.024, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 42.7, median = 34.8 mean = 39, median = 31.9
TEfus+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.09, hr = 0.89 af = 1, hr = 1
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.023, shape = 1.3 scale = 0.024, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 40.5, median = 33.1 mean = 39, median = 31.9
PI3K+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1.04, hr = 0.95 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
—- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
—+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
–+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
–++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 39, median = 31.9 mean = 39, median = 31.9
-+++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+— effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+–+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+–+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+-+- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+-+- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+-++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+-++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
++– param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
++– effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
++-+ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
++-+ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
+++- param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
+++- effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1
++++ param scale = 0.024, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.027, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.024, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 34.3, median = 28 mean = 34.3, median = 28 mean = 78.1, median = 63.8 mean = 39, median = 31.9
++++ effect af = 1, hr = 1 af = 0.88, hr = 1.18 af = 0.88, hr = 1.18 af = 2, hr = 0.41 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 6 3 73 26
HRD+ 2 3 321 21
TP53+ 9 3 49 26
TEfus+ 6 7 52 21
PI3K+ 3 1 44 13
TC1 TC2 TC3 TC4
all 0.012 0.006 0.146 0.052
HRD+ 0.004 0.006 0.642 0.042
TP53+ 0.018 0.006 0.098 0.052
TEfus+ 0.012 0.014 0.104 0.042
PI3K+ 0.006 0.002 0.088 0.026
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 15 24 0 1
HRD+ 8 6 0 10
TP53+ 106 140 17 47
TEfus+ 83 93 2 29
PI3K+ 73 97 2 54
TC1 TC2 TC3 TC4
all 0.030 0.048 0.000 0.002
HRD+ 0.016 0.012 0.000 0.020
TP53+ 0.212 0.280 0.034 0.094
TEfus+ 0.166 0.186 0.004 0.058
PI3K+ 0.146 0.194 0.004 0.108
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.376 0.05 0.034 0.170 0.172
Error subgroup 0.492 0.05 0.034 0.334 0.172
Power signature 0.642 0.00 0.000 0.642 0.000
Power subgroup 0.812 0.00 0.000 0.812 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 6 3 73 26
all futility 0 15 24 0 1
all max_n 0 0 0 0 0
all n 612 (562, 676) 263 (188, 354) 262 (181, 354) 328 (164, 428) 338 (233, 446)
all n_unique 612 (562, 676) 263 (188, 354) 262 (181, 354) 328 (164, 428) 338 (233, 446)
all time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (28, 60) 60 (60, 60)
all time_stop NA (NA, NA) 30 (10, 53) 36 (11, 55) 20 (12, 49) 15 (12, 36)
all post_p NA (NA, NA) 0.28 (0.04, 0.75) 0.3 (0.04, 0.75) 0.99 (0.9, 1) 0.84 (0.38, 0.99)
all rate 0.023 (0.022, 0.025) 0.025 (0.022, 0.028) 0.025 (0.023, 0.028) 0.018 (0.017, 0.02) 0.021 (0.019, 0.024)
HRD+ graduation 0 2 3 321 21
HRD+ futility 0 8 6 0 10
HRD+ max_n 0 0 0 0 0
HRD+ n 85 (71, 100) 38 (23, 57) 38 (24, 54) 52 (34, 72) 43 (27, 61)
HRD+ n_unique 85 (71, 100) 38 (23, 57) 38 (24, 54) 52 (34, 72) 43 (27, 61)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 51 (39, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 56 (50, 60) 58 (48, 60) 45 (37, 55) 53 (41, 59)
HRD+ post_p NA (NA, NA) 0.36 (0.08, 0.8) 0.37 (0.07, 0.8) 1 (0.98, 1) 0.55 (0.15, 0.94)
HRD+ rate 0.023 (0.019, 0.028) 0.025 (0.019, 0.033) 0.024 (0.018, 0.033) 0.009 (0.007, 0.013) 0.022 (0.016, 0.029)
TP53+ graduation 0 9 3 49 26
TP53+ futility 0 106 140 17 47
TP53+ max_n 0 0 0 0 0
TP53+ n 228 (202, 260) 100 (55, 152) 102 (54, 149) 113 (51, 165) 125 (59, 178)
TP53+ n_unique 228 (202, 260) 100 (55, 152) 102 (54, 149) 113 (51, 165) 125 (59, 178)
TP53+ time_trial 60 (60, 60) 60 (40, 60) 60 (29, 60) 60 (47, 60) 60 (42, 60)
TP53+ time_stop NA (NA, NA) 42 (28, 54) 35 (21, 52) 36 (24, 56) 35 (26, 57)
TP53+ post_p NA (NA, NA) 0.36 (0.06, 0.8) 0.38 (0.05, 0.81) 0.82 (0.36, 0.98) 0.72 (0.25, 0.97)
TP53+ rate 0.023 (0.02, 0.026) 0.025 (0.021, 0.031) 0.025 (0.022, 0.031) 0.02 (0.017, 0.025) 0.021 (0.018, 0.026)
TEfus+ graduation 0 6 7 52 21
TEfus+ futility 0 83 93 2 29
TEfus+ max_n 0 0 0 0 0
TEfus+ n 197 (172, 224) 89 (56, 128) 90 (53, 137) 100 (50, 139) 109 (59, 151)
TEfus+ n_unique 197 (172, 224) 89 (56, 128) 90 (53, 137) 100 (50, 139) 109 (59, 151)
TEfus+ time_trial 60 (60, 60) 60 (44, 60) 60 (40, 60) 60 (56, 60) 60 (60, 60)
TEfus+ time_stop NA (NA, NA) 42 (31, 56) 40 (29, 56) 41 (30, 54) 36 (25, 56)
TEfus+ post_p NA (NA, NA) 0.36 (0.06, 0.81) 0.35 (0.06, 0.8) 0.94 (0.64, 1) 0.71 (0.2, 0.96)
TEfus+ rate 0.023 (0.02, 0.026) 0.025 (0.021, 0.031) 0.025 (0.021, 0.031) 0.018 (0.015, 0.021) 0.021 (0.018, 0.026)
PI3K+ graduation 0 3 1 44 13
PI3K+ futility 0 73 97 2 54
PI3K+ max_n 0 0 0 0 0
PI3K+ n 212 (187, 239) 100 (59, 142) 97 (54, 145) 105 (50, 146) 121 (57, 172)
PI3K+ n_unique 212 (187, 239) 100 (59, 142) 97 (54, 145) 105 (50, 146) 121 (57, 172)
PI3K+ time_trial 60 (60, 60) 60 (50, 60) 60 (41, 60) 60 (60, 60) 60 (44, 60)
PI3K+ time_stop NA (NA, NA) 43 (30, 56) 39 (28, 57) 39 (26, 54) 33 (24, 53)
PI3K+ post_p NA (NA, NA) 0.4 (0.07, 0.82) 0.37 (0.06, 0.79) 0.85 (0.42, 0.98) 0.73 (0.24, 0.97)
PI3K+ rate 0.023 (0.02, 0.026) 0.024 (0.021, 0.03) 0.025 (0.021, 0.031) 0.02 (0.016, 0.024) 0.022 (0.018, 0.026)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 6 3 73 26
—- futility 0 15 24 0 1
—- max_n 0 0 0 0 0
—- n 190 (158, 224) 63 (28, 141) 60 (25, 134) 98 (25, 179) 104 (29, 181)
—- n_unique 190 (158, 224) 63 (28, 141) 60 (25, 134) 98 (25, 179) 104 (29, 181)
—- post_p NA (NA, NA) 0.34 (0.06, 0.79) 0.32 (0.07, 0.78) 0.68 (0.21, 0.97) 0.67 (0.2, 0.96)
—- rate 0.023 (0.02, 0.026) 0.027 (0.021, 0.035) 0.026 (0.021, 0.035) 0.021 (0.017, 0.028) 0.021 (0.017, 0.028)
—+ graduation 0 9 4 105 36
—+ futility 0 80 107 2 54
—+ max_n 0 0 0 0 0
—+ n 42 (33, 53) 19 (9, 37) 17 (8, 37) 20 (7, 41) 22 (9, 42)
—+ n_unique 42 (33, 53) 19 (9, 37) 17 (8, 37) 20 (7, 41) 22 (9, 42)
—+ post_p NA (NA, NA) 0.42 (0.1, 0.81) 0.44 (0.11, 0.8) 0.6 (0.19, 0.92) 0.58 (0.17, 0.91)
—+ rate 0.023 (0.017, 0.03) 0.026 (0.017, 0.04) 0.025 (0.017, 0.042) 0.022 (0.013, 0.036) 0.022 (0.015, 0.036)
–+- graduation 0 12 10 117 44
–+- futility 0 89 104 2 29
–+- max_n 0 0 0 0 0
–+- n 12 (8, 19) 7 (3, 13) 7 (3, 13) 6 (2, 12) 6 (2, 13)
–+- n_unique 12 (8, 19) 7 (3, 13) 7 (3, 13) 6 (2, 12) 6 (2, 13)
–+- post_p NA (NA, NA) 0.45 (0.17, 0.79) 0.45 (0.18, 0.75) 0.52 (0.24, 0.81) 0.51 (0.22, 0.8)
–+- rate 0.023 (0.012, 0.036) 0.026 (0.012, 0.056) 0.025 (0.012, 0.053) 0.022 (0.008, 0.048) 0.024 (0.01, 0.055)
–++ graduation 0 14 11 140 53
–++ futility 0 135 159 4 75
–++ max_n 0 0 0 0 0
–++ n 66 (51, 79) 24 (10, 53) 23 (10, 57) 26 (9, 57) 32 (13, 65)
–++ n_unique 66 (51, 79) 24 (10, 53) 23 (10, 57) 26 (9, 57) 32 (13, 65)
–++ post_p NA (NA, NA) 0.43 (0.09, 0.81) 0.38 (0.08, 0.81) 0.61 (0.17, 0.92) 0.58 (0.18, 0.93)
–++ rate 0.023 (0.018, 0.029) 0.026 (0.019, 0.038) 0.026 (0.019, 0.042) 0.022 (0.015, 0.036) 0.022 (0.016, 0.032)
-+– graduation 0 15 5 111 48
-+– futility 0 113 150 17 47
-+– max_n 0 0 0 0 0
-+– n 81 (65, 98) 30 (13, 68) 28 (14, 59) 33 (11, 76) 40 (13, 76)
-+– n_unique 81 (65, 98) 30 (13, 68) 28 (14, 59) 33 (11, 76) 40 (13, 76)
-+– post_p NA (NA, NA) 0.42 (0.07, 0.83) 0.41 (0.08, 0.82) 0.61 (0.16, 0.94) 0.6 (0.19, 0.92)
-+– rate 0.023 (0.019, 0.028) 0.026 (0.019, 0.038) 0.026 (0.019, 0.037) 0.022 (0.016, 0.033) 0.022 (0.016, 0.033)
-+-+ graduation 0 18 6 135 57
-+-+ futility 0 156 192 19 86
-+-+ max_n 0 0 0 0 0
-+-+ n 53 (42, 66) 20 (8, 47) 20 (9, 45) 22 (8, 47) 27 (11, 53)
-+-+ n_unique 53 (42, 66) 20 (8, 47) 20 (9, 45) 22 (8, 47) 27 (11, 53)
-+-+ post_p NA (NA, NA) 0.42 (0.1, 0.84) 0.41 (0.09, 0.79) 0.59 (0.2, 0.91) 0.6 (0.18, 0.93)
-+-+ rate 0.023 (0.018, 0.029) 0.025 (0.017, 0.041) 0.026 (0.019, 0.04) 0.022 (0.014, 0.036) 0.021 (0.015, 0.033)
-++- graduation 0 20 12 149 61
-++- futility 0 163 206 19 71
-++- max_n 0 0 0 0 0
-++- n 47 (37, 59) 17 (8, 39) 18 (9, 40) 20 (7, 44) 23 (7, 47)
-++- n_unique 47 (37, 59) 17 (8, 39) 18 (9, 40) 20 (7, 44) 23 (7, 47)
-++- post_p NA (NA, NA) 0.39 (0.09, 0.83) 0.39 (0.1, 0.79) 0.6 (0.19, 0.91) 0.59 (0.21, 0.93)
-++- rate 0.023 (0.017, 0.03) 0.026 (0.018, 0.043) 0.026 (0.018, 0.04) 0.021 (0.014, 0.035) 0.021 (0.014, 0.033)
-+++ graduation 0 22 13 166 69
-+++ futility 0 193 234 21 106
-+++ max_n 0 0 0 0 0
-+++ n 36 (28, 47) 15 (6, 33) 14 (6, 35) 15 (5, 32) 18 (7, 37)
-+++ n_unique 36 (28, 47) 15 (6, 33) 14 (6, 35) 15 (5, 32) 18 (7, 37)
-+++ post_p NA (NA, NA) 0.44 (0.12, 0.78) 0.4 (0.13, 0.8) 0.58 (0.2, 0.87) 0.53 (0.21, 0.86)
-+++ rate 0.023 (0.017, 0.031) 0.026 (0.017, 0.042) 0.027 (0.016, 0.042) 0.022 (0.014, 0.04) 0.023 (0.015, 0.036)
+— graduation 0 8 6 385 47
+— futility 0 22 30 0 11
+— max_n 0 0 0 0 0
+— n 41 (32, 51) 16 (7, 30) 15 (7, 31) 27 (14, 40) 18 (7, 31)
+— n_unique 41 (32, 51) 16 (7, 30) 15 (7, 31) 27 (14, 40) 18 (7, 31)
+— post_p NA (NA, NA) 0.38 (0.1, 0.79) 0.38 (0.1, 0.8) 0.98 (0.81, 1) 0.5 (0.16, 0.86)
+— rate 0.023 (0.017, 0.031) 0.025 (0.016, 0.043) 0.025 (0.015, 0.043) 0.009 (0.005, 0.015) 0.022 (0.014, 0.036)
+–+ graduation 0 11 7 391 54
+–+ futility 0 86 111 2 61
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+–+ rate 0 (0, 0) 0 (0, 0) 0 (0, 0.174) 0 (0, 0) 0 (0, 0.02)
+-+- graduation 0 14 13 395 64
+-+- futility 0 96 109 2 37
+-+- max_n 0 0 0 0 0
+-+- n 28 (21, 38) 11 (5, 22) 11 (5, 22) 18 (8, 27) 13 (5, 25)
+-+- n_unique 28 (21, 38) 11 (5, 22) 11 (5, 22) 18 (8, 27) 13 (5, 25)
+-+- post_p NA (NA, NA) 0.36 (0.1, 0.74) 0.37 (0.11, 0.74) 0.94 (0.73, 1) 0.52 (0.17, 0.87)
+-+- rate 0.023 (0.016, 0.031) 0.026 (0.015, 0.05) 0.026 (0.014, 0.049) 0.009 (0.005, 0.016) 0.021 (0.011, 0.041)
+-++ graduation 0 16 14 400 71
+-++ futility 0 141 163 4 82
+-++ max_n 0 0 0 0 0
+-++ n 6 (3, 10) 4 (1, 7) 3 (1, 6) 3 (1, 6) 4 (1, 7)
+-++ n_unique 6 (3, 10) 4 (1, 7) 3 (1, 6) 3 (1, 6) 4 (1, 7)
+-++ post_p NA (NA, NA) 0.48 (0.28, 0.65) 0.46 (0.28, 0.65) 0.59 (0.45, 0.78) 0.48 (0.29, 0.67)
+-++ rate 0.025 (0.007, 0.048) 0.024 (0, 0.055) 0.027 (0, 0.081) 0.009 (0, 0.031) 0.022 (0, 0.056)
++– graduation 0 15 8 392 66
++– futility 0 120 154 8 56
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
++– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
++– post_p NA (NA, NA) 0.49 (0.43, 0.57) 0.49 (0.43, 0.56) 0.53 (0.45, 0.59) 0.51 (0.44, 0.57)
++– rate 0.022 (0, 0.086) 0.022 (0, 0.092) 0.027 (0, 0.108) 0 (0, 0.049) 0.016 (0, 0.1)
++-+ graduation 0 18 9 397 72
++-+ futility 0 162 194 10 92
++-+ max_n 0 0 0 0 0
++-+ n 7 (4, 12) 4 (1, 8) 4 (1, 8) 4 (1, 9) 5 (2, 9)
++-+ n_unique 7 (4, 12) 4 (1, 8) 4 (1, 8) 4 (1, 9) 5 (2, 9)
++-+ post_p NA (NA, NA) 0.44 (0.25, 0.67) 0.46 (0.25, 0.69) 0.64 (0.47, 0.89) 0.47 (0.26, 0.7)
++-+ rate 0.023 (0.01, 0.044) 0.027 (0.008, 0.069) 0.025 (0.006, 0.062) 0.008 (0, 0.024) 0.023 (0.008, 0.055)
+++- graduation 0 20 15 399 78
+++- futility 0 170 209 10 78
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+++- rate 0 (0, 0.135) 0.086 (0.017, 0.177) 0.053 (0.049, 0.056) 0 (0, 0.041) 0 (0, 0)
++++ graduation 0 22 16 403 84
++++ futility 0 199 236 12 112
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) 0.52 (0.51, 0.52) 0.51 (0.48, 0.54) 0.51 (0.48, 0.54) 0.52 (0.51, 0.52)
++++ rate 0 (0, 0.195) 0.021 (0, 0.092) 0.036 (0, 0.127) 0.007 (0, 0.084) 0.015 (0, 0.087)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 6 3 73 26
all time_stop 10 (9, 19) 11 (11, 17) 20 (12, 49) 15 (12, 32)
all n_trt 66 (60, 120) 72 (72, 100) 110 (60, 276) 86 (56, 217)
all n_control 80 (71, 162) 95 (89, 135) 166 (99, 477) 122 (94, 285)
all post_p 0.96 (0.88, 0.99) 0.94 (0.92, 0.96) 0.97 (0.91, 1) 0.96 (0.91, 0.99)
all order 1 (1, 1.5) 1 (1, 1) 1 (1, 2.8) 1 (1, 2)
HRD+ count 2 3 321 21
HRD+ time_stop 55 (51, 59) 49 (45, 58) 45 (37, 55) 50 (41, 58)
HRD+ n_trt 52 (51, 54) 50 (50, 51) 52 (50, 64) 52 (50, 62)
HRD+ n_control 76 (74, 78) 69 (66, 84) 59 (44, 77) 67 (49, 76)
HRD+ post_p 0.94 (0.89, 0.99) 0.99 (0.94, 0.99) 1 (0.96, 1) 0.97 (0.92, 1)
HRD+ order 2 (2, 2) 2 (2, 2) 1 (1, 2) 2 (1, 3)
TP53+ count 9 3 49 26
TP53+ time_stop 26 (23, 55) 48 (45, 54) 35 (24, 53) 36 (23, 56)
TP53+ n_trt 60 (52, 143) 105 (103, 119) 75 (51, 115) 80 (55, 152)
TP53+ n_control 85 (68, 213) 183 (147, 189) 114 (73, 208) 124 (72, 198)
TP53+ post_p 0.96 (0.92, 0.98) 0.97 (0.94, 0.99) 0.97 (0.93, 1) 0.97 (0.9, 1)
TP53+ order 1 (1, 2) 2 (1.2, 2.8) 1 (1, 3) 2 (1, 3.5)
TEfus+ count 6 7 52 21
TEfus+ time_stop 28 (25, 38) 36 (33, 47) 41 (30, 54) 28 (24, 48)
TEfus+ n_trt 54 (51, 62) 92 (57, 103) 81 (55, 124) 61 (50, 109)
TEfus+ n_control 78 (61, 114) 118 (91, 135) 127 (77, 173) 81 (64, 156)
TEfus+ post_p 0.95 (0.86, 0.97) 0.94 (0.88, 0.99) 0.99 (0.94, 1) 0.99 (0.89, 1)
TEfus+ order 1 (1, 1.5) 1 (1, 2.8) 2 (1, 3) 1 (1, 3)
PI3K+ count 3 1 44 13
PI3K+ time_stop 32 (27, 38) 33 (33, 33) 39 (26, 55) 45 (27, 56)
PI3K+ n_trt 64 (56, 69) 67 (67, 67) 76 (51, 124) 104 (62, 140)
PI3K+ n_control 86 (69, 108) 112 (112, 112) 124 (72, 195) 143 (82, 195)
PI3K+ post_p 0.94 (0.89, 0.98) 0.96 (0.96, 0.96) 0.99 (0.95, 1) 0.99 (0.96, 1)
PI3K+ order 1 (1, 1) 1 (1, 1) 2 (1, 3.7) 2 (1, 4)
Futility:
signature var TC1 TC2 TC3 TC4
all count 15 24 1
all time_stop 41 (22, 53) 38 (11, 56) 40 (40, 40)
all n_trt 152 (102, 243) 138 (67, 216) 132 (132, 132)
all n_control 426 (180, 549) 354 (90, 592) 367 (367, 367)
all post_p 0.01 (0, 0.09) 0.03 (0, 0.16) 0.02 (0.02, 0.02)
all order 2 (1, 4) 2.5 (1, 4.7) 3 (3, 3)
HRD+ count 8 6 10
HRD+ time_stop 56 (53, 59) 58 (52, 60) 57 (52, 60)
HRD+ n_trt 55 (52, 57) 50 (50, 64) 54 (50, 60)
HRD+ n_control 87 (73, 96) 80 (72, 86) 80 (69, 100)
HRD+ post_p 0.17 (0.01, 0.29) 0.2 (0.07, 0.28) 0.2 (0.12, 0.27)
HRD+ order 2.5 (1, 5) 2.5 (1.5, 4.5) 2.5 (1.9, 4)
TP53+ count 106 140 17 47
TP53+ time_stop 42 (30, 54) 34 (21, 52) 41 (29, 56) 35 (27, 56)
TP53+ n_trt 66 (50, 98) 62 (51, 98) 54 (51, 115) 59 (50, 94)
TP53+ n_control 153 (88, 202) 115 (62, 190) 135 (95, 217) 117 (81, 212)
TP53+ post_p 0.1 (0.01, 0.23) 0.11 (0.02, 0.25) 0.13 (0.04, 0.23) 0.12 (0.03, 0.24)
TP53+ order 2 (1, 3) 1 (1, 3) 1 (1, 2.4) 2 (1, 3)
TEfus+ count 83 93 2 29
TEfus+ time_stop 42 (32, 57) 40 (29, 56) 38 (34, 41) 39 (30, 57)
TEfus+ n_trt 66 (52, 95) 61 (51, 92) 66 (53, 78) 63 (50, 92)
TEfus+ n_control 130 (87, 186) 118 (73, 187) 112 (104, 119) 114 (82, 190)
TEfus+ post_p 0.1 (0.02, 0.21) 0.1 (0.02, 0.19) 0.12 (0.11, 0.13) 0.14 (0.03, 0.26)
TEfus+ order 2 (1, 3) 2 (1, 3.8) 1 (1, 1) 1 (1, 3.2)
PI3K+ count 73 97 2 54
PI3K+ time_stop 44 (30, 57) 39 (28, 57) 46 (44, 48) 32 (23, 48)
PI3K+ n_trt 65 (50, 98) 62 (51, 95) 70 (65, 74) 57 (50, 90)
PI3K+ n_control 144 (87, 198) 128 (76, 203) 160 (149, 172) 100 (62, 154)
PI3K+ post_p 0.09 (0.03, 0.21) 0.1 (0.02, 0.2) 0.09 (0.08, 0.09) 0.13 (0.04, 0.25)
PI3K+ order 2 (1, 3) 2 (1, 4) 2.5 (1.3, 3.7) 1.5 (1, 3)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
all TC1 time 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19) 10 (9, 19)
all TC1 n 28 (23, 39) 6 (4, 16) 1 (0, 2) 7 (3, 14) 9 (6, 15) 6 (5, 11) 4 (3, 12) 4 (0, 6) 4 (1, 6) 0 (0, 0) 2 (0, 4) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.64 (0.6, 0.78) 0.55 (0.52, 0.76) 0.51 (0.51, 0.52) 0.58 (0.52, 0.61) 0.56 (0.53, 0.57) 0.53 (0.51, 0.6) 0.57 (0.54, 0.61) 0.53 (0.5, 0.53) 0.53 (0.5, 0.58) NA (NA, NA) 0.53 (0.51, 0.56) 0.56 (0.56, 0.56) NA (NA, NA) 0.52 (0.51, 0.53) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.009 (0, 0.015) 0 (0, 0.002) 0 (0, 0) 0 (0, 0.027) 0 (0, 0.011) 0 (0, 0.017) 0 (0, 0.011) 0 (0, 0.007) 0 (0, 0.007) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC2 time 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17) 11 (11, 17)
all TC2 n 26 (24, 28) 2 (2, 10) 1 (0, 3) 8 (6, 9) 16 (15, 21) 8 (8, 11) 8 (4, 9) 5 (2, 5) 3 (3, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 1 (0, 2) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.52 (0.51, 0.61) 0.53 (0.52, 0.57) 0.53 (0.52, 0.54) 0.56 (0.56, 0.68) 0.56 (0.55, 0.61) 0.5 (0.5, 0.65) 0.57 (0.54, 0.57) 0.54 (0.53, 0.56) 0.53 (0.51, 0.53) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA) NA (NA, NA) 0.51 (0.51, 0.52) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.013 (0.008, 0.019) 0 (0, 0.016) 0.014 (0.003, 0.024) 0 (0, 0.019) 0.005 (0.001, 0.008) 0.021 (0.004, 0.024) 0 (0, 0.008) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC3 count 73 73 73 73 73 73 73 73 73 73 73 73 73 73 73 73
all TC3 time 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49) 20 (12, 49)
all TC3 n 31 (14, 92) 7 (3, 23) 2 (0, 7) 10 (4, 27) 14 (6, 32) 8 (3, 23) 8 (3, 19) 7 (2, 18) 12 (7, 25) 0 (0, 0) 9 (4, 16) 1 (0, 5) 0 (0, 1) 2 (0, 6) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.65 (0.54, 0.89) 0.56 (0.51, 0.82) 0.55 (0.51, 0.78) 0.56 (0.52, 0.78) 0.58 (0.51, 0.82) 0.58 (0.52, 0.8) 0.56 (0.51, 0.72) 0.56 (0.52, 0.78) 0.59 (0.52, 0.99) NA (NA, NA) 0.57 (0.51, 0.85) 0.54 (0.51, 0.62) 0.56 (0.52, 0.57) 0.53 (0.5, 0.62) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.013 (0, 0.021) 0 (0, 0.02) 0 (0, 0.017) 0.011 (0, 0.023) 0.009 (0, 0.024) 0.007 (0, 0.022) 0 (0, 0.021) 0.01 (0, 0.022) 0.004 (0, 0.013) NA (NA, NA) 0 (0, 0.017) 0 (0, 0.017) 0 (0, 0.014) 0 (0, 0.011) NA (NA, NA) 0 (0, 0)
all TC4 count 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26
all TC4 time 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32) 15 (12, 32)
all TC4 n 25 (14, 70) 7 (3, 16) 1 (0, 4) 12 (5, 26) 9 (4, 28) 10 (4, 23) 5 (2, 10) 7 (4, 13) 4 (2, 16) 0 (0, 0) 3 (0, 7) 2 (0, 3) 0 (0, 1) 1 (0, 4) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.7 (0.54, 0.85) 0.56 (0.52, 0.64) 0.52 (0.51, 0.59) 0.56 (0.52, 0.82) 0.57 (0.53, 0.76) 0.57 (0.51, 0.81) 0.54 (0.51, 0.64) 0.55 (0.51, 0.65) 0.55 (0.51, 0.73) NA (NA, NA) 0.52 (0.5, 0.55) 0.54 (0.52, 0.59) 0.5 (0.5, 0.5) 0.53 (0.5, 0.57) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.01 (0, 0.019) 0 (0, 0.02) 0 (0, 0.012) 0.008 (0, 0.018) 0 (0, 0.017) 0 (0, 0.018) 0 (0, 0.027) 0 (0, 0.023) 0 (0, 0.016) 0 (0, 0) 0 (0, 0.017) 0 (0, 0.013) 0 (0, 0.014) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 2 2 2 2 2 2 2 2
HRD+ TC1 time 55 (51, 59) 55 (51, 59) 55 (51, 59) 55 (51, 59) 55 (51, 59) 55 (51, 59) 55 (51, 59) 55 (51, 59)
HRD+ TC1 n 30 (30, 30) 0 (0, 0) 16 (15, 16) 2 (1, 3) 0 (0, 0) 5 (4, 6) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.8 (0.73, 0.88) NA (NA, NA) 0.83 (0.74, 0.92) 0.57 (0.55, 0.6) NA (NA, NA) 0.58 (0.52, 0.65) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.013 (0.009, 0.017) NA (NA, NA) 0.01 (0.005, 0.015) 0.007 (0.001, 0.013) NA (NA, NA) 0.026 (0.018, 0.035) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 3 3 3 3 3 3 3 3
HRD+ TC2 time 49 (45, 58) 49 (45, 58) 49 (45, 58) 49 (45, 58) 49 (45, 58) 49 (45, 58) 49 (45, 58) 49 (45, 58)
HRD+ TC2 n 28 (26, 30) 0 (0, 0) 12 (10, 17) 2 (0, 4) 0 (0, 2) 6 (4, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.91 (0.85, 0.98) NA (NA, NA) 0.8 (0.69, 0.91) 0.59 (0.58, 0.59) NA (NA, NA) 0.59 (0.56, 0.65) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.014 (0.011, 0.015) NA (NA, NA) 0.01 (0.01, 0.021) 0.005 (0.001, 0.009) 0.107 (0.107, 0.107) 0.011 (0.009, 0.015) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 321 321 321 321 321 321 321 321
HRD+ TC3 time 45 (37, 55) 45 (37, 55) 45 (37, 55) 45 (37, 55) 45 (37, 55) 45 (37, 55) 45 (37, 55) 45 (37, 55)
HRD+ TC3 n 27 (20, 36) 0 (0, 0) 18 (10, 25) 3 (1, 6) 1 (0, 2) 5 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.94 (0.78, 1) NA (NA, NA) 0.87 (0.71, 0.99) 0.56 (0.51, 0.71) 0.54 (0.5, 0.58) 0.59 (0.52, 0.78) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.008 (0.004, 0.014) 0 (0, 0) 0.007 (0.003, 0.014) 0 (0, 0.023) 0 (0, 0.035) 0.006 (0, 0.019) 0.019 (0.004, 0.034) 0.01 (0, 0.169)
HRD+ TC4 count 21 21 21 21 21 21 21 21
HRD+ TC4 time 50 (41, 58) 50 (41, 58) 50 (41, 58) 50 (41, 58) 50 (41, 58) 50 (41, 58) 50 (41, 58) 50 (41, 58)
HRD+ TC4 n 26 (18, 30) 0 (0, 0) 17 (10, 25) 5 (1, 7) 1 (0, 2) 6 (3, 9) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.82 (0.73, 0.94) NA (NA, NA) 0.82 (0.71, 0.94) 0.56 (0.51, 0.64) 0.53 (0.52, 0.56) 0.59 (0.53, 0.77) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.012 (0.007, 0.02) NA (NA, NA) 0.011 (0.004, 0.019) 0.011 (0, 0.022) 0 (0, 0.018) 0.014 (0.008, 0.028) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 9 9 9 9 9 9 9 9
TP53+ TC1 time 26 (23, 55) 26 (23, 55) 26 (23, 55) 26 (23, 55) 26 (23, 55) 26 (23, 55) 26 (23, 55) 26 (23, 55)
TP53+ TC1 n 27 (20, 39) 16 (10, 38) 22 (6, 33) 10 (3, 34) 0 (0, 0) 3 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.75 (0.72, 0.83) 0.72 (0.53, 0.89) 0.76 (0.53, 0.94) 0.71 (0.55, 0.83) 0.63 (0.63, 0.63) 0.53 (0.52, 0.68) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.016 (0.007, 0.022) 0.013 (0.006, 0.019) 0.011 (0, 0.023) 0 (0, 0.015) 0 (0, 0) 0.013 (0, 0.024) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 3 3 3 3 3 3 3 3
TP53+ TC2 time 48 (45, 54) 48 (45, 54) 48 (45, 54) 48 (45, 54) 48 (45, 54) 48 (45, 54) 48 (45, 54) 48 (45, 54)
TP53+ TC2 n 35 (30, 42) 33 (27, 34) 22 (12, 33) 15 (11, 21) 0 (0, 0) 5 (3, 7) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.86 (0.74, 0.95) 0.71 (0.71, 0.79) 0.71 (0.58, 0.77) 0.81 (0.66, 0.95) NA (NA, NA) 0.51 (0.51, 0.56) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.02 (0.016, 0.02) 0.018 (0.013, 0.019) 0.018 (0.017, 0.026) 0.015 (0.011, 0.019) NA (NA, NA) 0.014 (0.012, 0.018) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 49 49 49 49 49 49 49 49
TP53+ TC3 time 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53) 35 (24, 53)
TP53+ TC3 n 24 (16, 50) 19 (8, 35) 12 (6, 34) 10 (6, 20) 0 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.76 (0.71, 0.92) 0.75 (0.56, 0.89) 0.73 (0.52, 0.95) 0.73 (0.53, 0.87) 0.54 (0.51, 0.57) 0.55 (0.51, 0.69) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.013 (0.005, 0.019) 0.013 (0, 0.02) 0.014 (0, 0.023) 0.015 (0, 0.023) 0 (0, 0.028) 0 (0, 0.014) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 26 26 26 26 26 26 26 26
TP53+ TC4 time 36 (23, 56) 36 (23, 56) 36 (23, 56) 36 (23, 56) 36 (23, 56) 36 (23, 56) 36 (23, 56) 36 (23, 56)
TP53+ TC4 n 31 (21, 61) 20 (13, 42) 10 (6, 36) 10 (6, 27) 0 (0, 2) 4 (2, 8) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.8 (0.74, 0.91) 0.77 (0.72, 0.9) 0.72 (0.52, 0.86) 0.68 (0.55, 0.82) 0.52 (0.51, 0.55) 0.56 (0.51, 0.72) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.012 (0.009, 0.018) 0.013 (0.004, 0.019) 0.013 (0, 0.022) 0.015 (0, 0.022) 0 (0, 0.028) 0 (0, 0.021) NA (NA, NA) 0 (0, 0)
TEfus+ TC1 count 6 6 6 6 6 6 6 6
TEfus+ TC1 time 28 (25, 38) 28 (25, 38) 28 (25, 38) 28 (25, 38) 28 (25, 38) 28 (25, 38) 28 (25, 38) 28 (25, 38)
TEfus+ TC1 n 3 (2, 4) 22 (11, 24) 12 (8, 19) 10 (7, 16) 8 (4, 10) 2 (1, 3) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.53 (0.51, 0.61) 0.75 (0.62, 0.84) 0.73 (0.55, 0.9) 0.63 (0.52, 0.73) 0.56 (0.52, 0.66) 0.55 (0.5, 0.59) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.009 (0, 0.034) 0.016 (0.006, 0.025) 0.007 (0.006, 0.016) 0.018 (0.003, 0.022) 0.01 (0, 0.014) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 count 7 7 7 7 7 7 7 7
TEfus+ TC2 time 36 (33, 47) 36 (33, 47) 36 (33, 47) 36 (33, 47) 36 (33, 47) 36 (33, 47) 36 (33, 47) 36 (33, 47)
TEfus+ TC2 n 5 (5, 6) 30 (13, 34) 23 (16, 35) 21 (9, 27) 9 (8, 10) 1 (0, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.55 (0.51, 0.63) 0.76 (0.74, 0.96) 0.78 (0.74, 0.86) 0.72 (0.53, 0.81) 0.57 (0.52, 0.63) 0.58 (0.57, 0.64) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.019 (0.011, 0.029) 0.016 (0.01, 0.019) 0.014 (0.007, 0.02) 0.015 (0.011, 0.026) 0.012 (0.005, 0.018) 0 (0, 0.009) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 52 52 52 52 52 52 52 52
TEfus+ TC3 time 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54) 41 (30, 54)
TEfus+ TC3 n 4 (1, 8) 25 (17, 45) 18 (8, 38) 14 (8, 22) 15 (8, 22) 2 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.6 (0.51, 0.75) 0.8 (0.71, 0.92) 0.75 (0.54, 0.95) 0.72 (0.57, 0.86) 0.79 (0.6, 0.97) 0.56 (0.52, 0.66) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.009 (0, 0.026) 0.014 (0.007, 0.02) 0.014 (0.008, 0.021) 0.013 (0, 0.02) 0.007 (0, 0.016) 0 (0, 0.026) NA (NA, NA) 0 (0, 0)
TEfus+ TC4 count 21 21 21 21 21 21 21 21
TEfus+ TC4 time 28 (24, 48) 28 (24, 48) 28 (24, 48) 28 (24, 48) 28 (24, 48) 28 (24, 48) 28 (24, 48) 28 (24, 48)
TEfus+ TC4 n 4 (1, 8) 26 (21, 37) 12 (5, 29) 11 (7, 18) 7 (5, 15) 2 (1, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.55 (0.51, 0.73) 0.83 (0.7, 0.97) 0.74 (0.51, 0.84) 0.71 (0.56, 0.83) 0.59 (0.51, 0.87) 0.53 (0.51, 0.56) NA (NA, NA) 0.53 (0.53, 0.53)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0.021) 0.012 (0.006, 0.016) 0.011 (0, 0.02) 0.012 (0.005, 0.016) 0.008 (0, 0.018) 0 (0, 0.024) NA (NA, NA) 0 (0, 0)
PI3K+ TC1 count 3 3 3 3 3 3 3 3
PI3K+ TC1 time 32 (27, 38) 32 (27, 38) 32 (27, 38) 32 (27, 38) 32 (27, 38) 32 (27, 38) 32 (27, 38) 32 (27, 38)
PI3K+ TC1 n 14 (11, 18) 23 (22, 25) 13 (7, 19) 12 (8, 13) 0 (0, 0) 1 (1, 2) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 post_p 0.7 (0.65, 0.74) 0.74 (0.73, 0.77) 0.82 (0.67, 0.84) 0.75 (0.61, 0.76) NA (NA, NA) 0.54 (0.53, 0.55) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.013 (0.01, 0.014) 0.018 (0.01, 0.018) 0.012 (0.012, 0.013) 0.012 (0.002, 0.015) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 1 1 1 1 1 1 1 1
PI3K+ TC2 time 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33) 33 (33, 33)
PI3K+ TC2 n 6 (6, 6) 29 (29, 29) 17 (17, 17) 8 (8, 8) 0 (0, 0) 2 (2, 2) 5 (5, 5) 0 (0, 0)
PI3K+ TC2 post_p 0.63 (0.63, 0.63) 0.86 (0.86, 0.86) 0.76 (0.76, 0.76) 0.6 (0.6, 0.6) NA (NA, NA) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.013 (0.013, 0.013) 0.009 (0.009, 0.009) 0.012 (0.012, 0.012) 0.022 (0.022, 0.022) NA (NA, NA) 0.194 (0.194, 0.194) 0.016 (0.016, 0.016) NA (NA, NA)
PI3K+ TC3 count 44 44 44 44 44 44 44 44
PI3K+ TC3 time 39 (26, 55) 39 (26, 55) 39 (26, 55) 39 (26, 55) 39 (26, 55) 39 (26, 55) 39 (26, 55) 39 (26, 55)
PI3K+ TC3 n 17 (7, 34) 23 (15, 36) 18 (10, 32) 13 (6, 21) 0 (0, 0) 2 (0, 6) 4 (1, 6) 0 (0, 0)
PI3K+ TC3 post_p 0.75 (0.54, 0.92) 0.8 (0.71, 0.92) 0.79 (0.62, 0.93) 0.73 (0.52, 0.92) NA (NA, NA) 0.54 (0.5, 0.7) 0.57 (0.51, 0.69) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.012 (0.002, 0.018) 0.012 (0.002, 0.019) 0.014 (0.001, 0.019) 0.013 (0, 0.022) 0 (0, 0) 0 (0, 0.026) 0 (0, 0.021) NA (NA, NA)
PI3K+ TC4 count 13 13 13 13 13 13 13 13
PI3K+ TC4 time 45 (27, 56) 45 (27, 56) 45 (27, 56) 45 (27, 56) 45 (27, 56) 45 (27, 56) 45 (27, 56) 45 (27, 56)
PI3K+ TC4 n 17 (8, 25) 28 (23, 51) 27 (16, 33) 15 (7, 23) 0 (0, 0) 3 (1, 7) 4 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.73 (0.65, 0.84) 0.87 (0.73, 0.99) 0.82 (0.71, 0.9) 0.76 (0.62, 0.89) NA (NA, NA) 0.54 (0.52, 0.61) 0.55 (0.52, 0.66) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.015 (0.013, 0.017) 0.013 (0.008, 0.022) 0.014 (0.006, 0.021) 0.013 (0.009, 0.02) NA (NA, NA) 0 (0, 0.023) 0.011 (0, 0.017) NA (NA, NA)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
all TC1 time 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53) 41 (22, 53)
all TC1 n 35 (24, 94) 11 (6, 19) 4 (2, 8) 15 (8, 30) 15 (9, 37) 8 (5, 24) 11 (8, 23) 8 (4, 15) 8 (5, 16) 0 (0, 0) 6 (4, 11) 1 (0, 4) 0 (0, 1) 3 (0, 4) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.15 (0.05, 0.44) 0.36 (0.22, 0.46) 0.41 (0.22, 0.49) 0.29 (0.09, 0.45) 0.28 (0.1, 0.48) 0.35 (0.1, 0.47) 0.36 (0.18, 0.47) 0.3 (0.18, 0.41) 0.4 (0.15, 0.49) NA (NA, NA) 0.33 (0.12, 0.48) 0.45 (0.41, 0.49) 0.48 (0.42, 0.49) 0.44 (0.34, 0.47) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.029 (0.022, 0.034) 0.03 (0.024, 0.042) 0.033 (0.018, 0.105) 0.027 (0.019, 0.041) 0.027 (0.021, 0.046) 0.028 (0.022, 0.067) 0.026 (0.016, 0.032) 0.036 (0.026, 0.07) 0.025 (0.018, 0.093) NA (NA, NA) 0.032 (0.022, 0.078) 0.031 (0, 0.463) 0.022 (0, 0.064) 0.051 (0.019, 0.205) NA (NA, NA) NA (NA, NA)
all TC2 count 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24
all TC2 time 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56) 38 (11, 56)
all TC2 n 30 (17, 91) 10 (2, 18) 4 (1, 9) 15 (7, 21) 14 (10, 26) 9 (5, 21) 10 (5, 22) 9 (4, 15) 6 (2, 17) 0 (0, 0) 5 (2, 12) 2 (0, 5) 0 (0, 1) 1 (0, 4) 0 (0, 0) 0 (0, 1)
all TC2 post_p 0.29 (0.12, 0.45) 0.34 (0.17, 0.49) 0.43 (0.22, 0.48) 0.37 (0.15, 0.45) 0.34 (0.09, 0.46) 0.29 (0.13, 0.47) 0.31 (0.15, 0.45) 0.37 (0.22, 0.48) 0.38 (0.19, 0.45) NA (NA, NA) 0.42 (0.16, 0.49) 0.46 (0.38, 0.49) 0.43 (0.43, 0.43) 0.45 (0.3, 0.5) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.027 (0.022, 0.033) 0.033 (0.014, 0.049) 0.027 (0, 0.051) 0.03 (0.021, 0.037) 0.03 (0.016, 0.037) 0.028 (0.018, 0.054) 0.031 (0.023, 0.047) 0.026 (0.017, 0.042) 0.029 (0.016, 0.069) NA (NA, NA) 0.028 (0, 0.078) 0.029 (0, 0.08) 0.019 (0, 0.04) 0.034 (0, 0.104) NA (NA, NA) 0 (0, 0)
all TC4 count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
all TC4 time 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40) 40 (40, 40)
all TC4 n 12 (12, 12) 7 (7, 7) 7 (7, 7) 25 (25, 25) 9 (9, 9) 18 (18, 18) 19 (19, 19) 4 (4, 4) 16 (16, 16) 0 (0, 0) 10 (10, 10) 3 (3, 3) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.09 (0.09, 0.09) 0.31 (0.31, 0.31) 0.11 (0.11, 0.11) 0.41 (0.41, 0.41) 0.23 (0.23, 0.23) 0.49 (0.49, 0.49) 0.41 (0.41, 0.41) 0.06 (0.06, 0.06) 0.48 (0.48, 0.48) NA (NA, NA) 0.43 (0.43, 0.43) 0.5 (0.5, 0.5) NA (NA, NA) 0.26 (0.26, 0.26) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.047 (0.047, 0.047) 0.037 (0.037, 0.037) 0.048 (0.048, 0.048) 0.024 (0.024, 0.024) 0.032 (0.032, 0.032) 0.021 (0.021, 0.021) 0.025 (0.025, 0.025) 0.081 (0.081, 0.081) 0.016 (0.016, 0.016) NA (NA, NA) 0.016 (0.016, 0.016) 0.02 (0.02, 0.02) NA (NA, NA) 0.091 (0.091, 0.091) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 8 8 8 8 8 8 8 8
HRD+ TC1 time 56 (53, 59) 56 (53, 59) 56 (53, 59) 56 (53, 59) 56 (53, 59) 56 (53, 59) 56 (53, 59) 56 (53, 59)
HRD+ TC1 n 26 (11, 34) 0 (0, 0) 18 (12, 28) 5 (2, 8) 0 (0, 1) 4 (3, 7) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.28 (0.12, 0.42) NA (NA, NA) 0.28 (0.15, 0.48) 0.42 (0.37, 0.48) 0.45 (0.45, 0.45) 0.42 (0.39, 0.46) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.026 (0.019, 0.033) NA (NA, NA) 0.027 (0.022, 0.038) 0.037 (0.027, 0.052) 0.018 (0.004, 0.049) 0.025 (0.019, 0.037) NA (NA, NA) 0 (0, 0)
HRD+ TC2 count 6 6 6 6 6 6 6 6
HRD+ TC2 time 58 (52, 60) 58 (52, 60) 58 (52, 60) 58 (52, 60) 58 (52, 60) 58 (52, 60) 58 (52, 60) 58 (52, 60)
HRD+ TC2 n 27 (18, 31) 0 (0, 0) 20 (12, 27) 4 (2, 6) 0 (0, 0) 4 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.26 (0.18, 0.38) NA (NA, NA) 0.32 (0.3, 0.37) 0.43 (0.33, 0.45) NA (NA, NA) 0.45 (0.38, 0.48) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.022 (0.019, 0.034) NA (NA, NA) 0.023 (0.02, 0.035) 0.026 (0.022, 0.042) 0.141 (0.141, 0.141) 0.023 (0.016, 0.038) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 10 10 10 10 10 10 10 10
HRD+ TC4 time 57 (52, 60) 57 (52, 60) 57 (52, 60) 57 (52, 60) 57 (52, 60) 57 (52, 60) 57 (52, 60) 57 (52, 60)
HRD+ TC4 n 26 (20, 36) 0 (0, 0) 14 (7, 24) 4 (3, 7) 0 (0, 3) 6 (4, 6) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.44 (0.4, 0.49) NA (NA, NA) 0.22 (0.18, 0.4) 0.43 (0.32, 0.48) 0.45 (0.45, 0.45) 0.39 (0.19, 0.45) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.02 (0.018, 0.027) 0 (0, 0) 0.03 (0.019, 0.037) 0.026 (0.02, 0.038) 0.037 (0.02, 0.053) 0.032 (0.023, 0.064) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 106 106 106 106 106 106 106 106
TP53+ TC1 time 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54)
TP53+ TC1 n 21 (11, 39) 14 (8, 24) 12 (7, 26) 11 (5, 25) 0 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.33 (0.07, 0.48) 0.32 (0.13, 0.47) 0.3 (0.12, 0.46) 0.38 (0.16, 0.48) 0.46 (0.41, 0.49) 0.44 (0.33, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.025 (0.019, 0.04) 0.027 (0.021, 0.045) 0.03 (0.02, 0.05) 0.028 (0.021, 0.045) 0.026 (0, 0.091) 0.035 (0.011, 0.083) 0 (0, 0) 0 (0, 0.026)
TP53+ TC2 count 140 140 140 140 140 140 140 140
TP53+ TC2 time 34 (21, 52) 34 (21, 52) 34 (21, 52) 34 (21, 52) 34 (21, 52) 34 (21, 52) 34 (21, 52) 34 (21, 52)
TP53+ TC2 n 20 (12, 37) 14 (7, 30) 14 (9, 24) 10 (6, 20) 0 (0, 1) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.33 (0.08, 0.48) 0.32 (0.12, 0.48) 0.38 (0.11, 0.48) 0.37 (0.17, 0.48) 0.47 (0.42, 0.5) 0.45 (0.32, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.026 (0.018, 0.037) 0.026 (0.018, 0.045) 0.027 (0.016, 0.04) 0.027 (0.018, 0.043) 0 (0, 0.089) 0.032 (0, 0.096) NA (NA, NA) 0.023 (0, 0.202)
TP53+ TC3 count 17 17 17 17 17 17 17 17
TP53+ TC3 time 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56) 41 (29, 56)
TP53+ TC3 n 19 (11, 49) 17 (8, 35) 12 (10, 20) 8 (5, 12) 0 (0, 2) 3 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.32 (0.16, 0.44) 0.39 (0.19, 0.48) 0.34 (0.2, 0.47) 0.34 (0.16, 0.46) 0.48 (0.48, 0.48) 0.48 (0.44, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.027 (0.021, 0.036) 0.026 (0.02, 0.034) 0.027 (0.02, 0.036) 0.032 (0.027, 0.078) 0 (0, 0.04) 0.018 (0, 0.042) 0 (0, 0) NA (NA, NA)
TP53+ TC4 count 47 47 47 47 47 47 47 47
TP53+ TC4 time 35 (27, 56) 35 (27, 56) 35 (27, 56) 35 (27, 56) 35 (27, 56) 35 (27, 56) 35 (27, 56) 35 (27, 56)
TP53+ TC4 n 20 (10, 38) 14 (9, 18) 12 (5, 27) 11 (6, 18) 0 (0, 1) 4 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.36 (0.17, 0.47) 0.34 (0.14, 0.47) 0.42 (0.21, 0.48) 0.35 (0.17, 0.47) 0.47 (0.42, 0.49) 0.45 (0.34, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.027 (0.018, 0.044) 0.026 (0.019, 0.043) 0.025 (0.02, 0.05) 0.027 (0.018, 0.044) 0 (0, 0.072) 0.031 (0.014, 0.1) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 83 83 83 83 83 83 83 83
TEfus+ TC1 time 42 (32, 57) 42 (32, 57) 42 (32, 57) 42 (32, 57) 42 (32, 57) 42 (32, 57) 42 (32, 57) 42 (32, 57)
TEfus+ TC1 n 5 (2, 8) 20 (10, 39) 14 (8, 29) 11 (5, 21) 8 (5, 17) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.41 (0.21, 0.49) 0.35 (0.12, 0.48) 0.34 (0.13, 0.48) 0.32 (0.14, 0.45) 0.36 (0.19, 0.48) 0.45 (0.33, 0.5) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.036 (0.016, 0.099) 0.025 (0.019, 0.038) 0.028 (0.021, 0.041) 0.03 (0.022, 0.047) 0.028 (0.02, 0.049) 0.032 (0.012, 0.071) NA (NA, NA) 0.039 (0.039, 0.039)
TEfus+ TC2 count 93 93 93 93 93 93 93 93
TEfus+ TC2 time 40 (29, 56) 40 (29, 56) 40 (29, 56) 40 (29, 56) 40 (29, 56) 40 (29, 56) 40 (29, 56) 40 (29, 56)
TEfus+ TC2 n 5 (3, 9) 18 (10, 35) 15 (9, 28) 11 (6, 19) 9 (4, 14) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.42 (0.26, 0.49) 0.28 (0.11, 0.47) 0.26 (0.11, 0.46) 0.34 (0.14, 0.47) 0.38 (0.18, 0.48) 0.45 (0.36, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.029 (0.018, 0.064) 0.027 (0.019, 0.043) 0.027 (0.019, 0.041) 0.03 (0.02, 0.044) 0.029 (0.019, 0.061) 0.036 (0, 0.086) NA (NA, NA) 0 (0, 0.137)
TEfus+ TC3 count 2 2 2 2 2 2 2 2
TEfus+ TC3 time 38 (34, 41) 38 (34, 41) 38 (34, 41) 38 (34, 41) 38 (34, 41) 38 (34, 41) 38 (34, 41) 38 (34, 41)
TEfus+ TC3 n 4 (3, 6) 18 (16, 19) 14 (11, 18) 16 (7, 24) 11 (10, 12) 2 (2, 3) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.44 (0.41, 0.46) 0.3 (0.25, 0.36) 0.28 (0.2, 0.36) 0.44 (0.39, 0.48) 0.42 (0.38, 0.46) 0.44 (0.44, 0.44) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.027 (0.025, 0.03) 0.025 (0.025, 0.025) 0.027 (0.024, 0.031) 0.03 (0.027, 0.033) 0.017 (0.015, 0.02) 0.013 (0.003, 0.023) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 29 29 29 29 29 29 29 29
TEfus+ TC4 time 39 (30, 57) 39 (30, 57) 39 (30, 57) 39 (30, 57) 39 (30, 57) 39 (30, 57) 39 (30, 57) 39 (30, 57)
TEfus+ TC4 n 4 (1, 8) 21 (13, 36) 14 (8, 21) 12 (6, 19) 9 (4, 15) 3 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.43 (0.21, 0.48) 0.36 (0.21, 0.47) 0.37 (0.17, 0.45) 0.39 (0.23, 0.47) 0.37 (0.15, 0.48) 0.45 (0.32, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.032 (0.022, 0.112) 0.023 (0.021, 0.034) 0.027 (0.021, 0.036) 0.026 (0.019, 0.042) 0.027 (0.015, 0.039) 0.034 (0.007, 0.09) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 73 73 73 73 73 73 73 73
PI3K+ TC1 time 44 (30, 57) 44 (30, 57) 44 (30, 57) 44 (30, 57) 44 (30, 57) 44 (30, 57) 44 (30, 57) 44 (30, 57)
PI3K+ TC1 n 13 (7, 22) 19 (9, 36) 15 (8, 25) 10 (6, 22) 0 (0, 0) 3 (1, 6) 3 (1, 6) 0 (0, 0)
PI3K+ TC1 post_p 0.33 (0.11, 0.46) 0.35 (0.14, 0.47) 0.32 (0.1, 0.47) 0.32 (0.13, 0.46) NA (NA, NA) 0.45 (0.33, 0.49) 0.45 (0.29, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.029 (0.021, 0.043) 0.026 (0.021, 0.04) 0.026 (0.02, 0.043) 0.03 (0.02, 0.052) NA (NA, NA) 0.033 (0.011, 0.083) 0.033 (0.015, 0.075) NA (NA, NA)
PI3K+ TC2 count 97 97 97 97 97 97 97 97
PI3K+ TC2 time 39 (28, 57) 39 (28, 57) 39 (28, 57) 39 (28, 57) 39 (28, 57) 39 (28, 57) 39 (28, 57) 39 (28, 57)
PI3K+ TC2 n 14 (7, 28) 18 (10, 29) 14 (9, 29) 11 (6, 20) 0 (0, 0) 2 (0, 5) 3 (1, 6) 0 (0, 0)
PI3K+ TC2 post_p 0.35 (0.12, 0.47) 0.32 (0.11, 0.48) 0.32 (0.11, 0.47) 0.34 (0.13, 0.47) NA (NA, NA) 0.45 (0.36, 0.49) 0.45 (0.29, 0.5) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.028 (0.02, 0.047) 0.028 (0.02, 0.04) 0.027 (0.02, 0.043) 0.028 (0.021, 0.045) 0.299 (0.299, 0.299) 0.034 (0, 0.088) 0.029 (0, 0.088) 0 (0, 0.037)
PI3K+ TC3 count 2 2 2 2 2 2 2 2
PI3K+ TC3 time 46 (44, 48) 46 (44, 48) 46 (44, 48) 46 (44, 48) 46 (44, 48) 46 (44, 48) 46 (44, 48) 46 (44, 48)
PI3K+ TC3 n 16 (14, 18) 17 (11, 23) 19 (17, 21) 15 (10, 20) 0 (0, 0) 1 (0, 2) 2 (1, 2) 0 (0, 0)
PI3K+ TC3 post_p 0.35 (0.33, 0.37) 0.22 (0.13, 0.31) 0.34 (0.3, 0.37) 0.35 (0.24, 0.47) NA (NA, NA) 0.48 (0.48, 0.48) 0.43 (0.41, 0.45) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.023 (0.02, 0.026) 0.033 (0.029, 0.037) 0.025 (0.022, 0.029) 0.027 (0.026, 0.028) NA (NA, NA) 0.031 (0.031, 0.031) 0.049 (0.038, 0.061) NA (NA, NA)
PI3K+ TC4 count 54 54 54 54 54 54 54 54
PI3K+ TC4 time 32 (23, 48) 32 (23, 48) 32 (23, 48) 32 (23, 48) 32 (23, 48) 32 (23, 48) 32 (23, 48) 32 (23, 48)
PI3K+ TC4 n 11 (6, 18) 17 (11, 27) 14 (9, 24) 10 (6, 16) 0 (0, 0) 2 (0, 5) 3 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.38 (0.19, 0.48) 0.37 (0.14, 0.49) 0.35 (0.16, 0.46) 0.38 (0.2, 0.48) NA (NA, NA) 0.44 (0.35, 0.49) 0.43 (0.31, 0.49) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.027 (0.016, 0.048) 0.025 (0.019, 0.04) 0.026 (0.019, 0.038) 0.026 (0.018, 0.046) NA (NA, NA) 0.031 (0, 0.135) 0.028 (0, 0.089) NA (NA, NA)